乌鲁木齐市男男性行为人群HIV/STD新发感染率及其影响因素  

HIV/STD incidence and risk factors among men who have sex with men(MSM) in Urumqi

作　　者：任晖琴[1] 地力夏提.亚克甫 米娜瓦尔.艾拜 王新迪[3] 

机构地区：[1]新疆医科大学公共卫生学院流行病与卫生统计学教研室,乌鲁木齐830011 [2]新疆维吾尔自治区卫生厅,乌鲁木齐830002 [3]乌鲁木齐市疾病预防控制中心,乌鲁木齐830026

出　　处：《新疆医科大学学报》2012年第11期1495-1499,共5页Journal of Xinjiang Medical University

基　　金：国家十一五科技重大专项课题(2008zx10001-016)

摘　　要：目的了解乌鲁木齐市男男性行为人群HIV/STD新发感染率及其影响因素,指导采取和调整相应的控制男男性行为人群HIV传播流行的措施和策略。方法调查对象为在乌鲁木齐市工作、生活或学习的男男性行为者,纳入标准为18岁及以上男性,近6个月有同性性行为,HIV检测为阴性,将在乌鲁木齐居住1a。在本底调查、6个月和12个月随访时每次进行检测前咨询、采集血样进行HIV、梅毒、生殖器疱疹病毒-2(HSV-2)抗体检测。结果 (1)HIV抗体阴性队列本底人数为340人,总观察时间为282人年,共有8人HIV血清抗体阳转,其HIV新发感染率为2.84/100人年;梅毒抗体阴性队列本底人数为311人,总观察时间为229人年,共有7人梅毒血清抗体阳转,其梅毒新发感染率为3.06/100人年;HSV-2抗体阴性队列本底人数为300人,总观察时间为293人年,共有14人HSV-2抗体阳转,其HSV-2新发感染率为4.78/100人年。多因素Cox回归模型分析结果显示,既往吸毒比不吸毒的更容易感染HIV和梅毒,近6个月有同性商业性行为的比没有同性商业性行为的更容易感染梅毒。(2)12个月随访中,近6个月男性性伴数、女性性伴数、近6个月与男性性伴无保护性肛交等均呈下降趋势(P均<0.01)。结论乌鲁木齐市男男性行为人群中,HIV、梅毒、HSV-2的新发感染情况已非常严重,应及时采取针对措施控制该人群中HIV/STD的流行传播。Objective To understand the HIV / STD infection rate and its risk factors,to control the spread of HIV among men who have sex with men（MSM）.Methods This study investigated MSM participant who working,living and studying in Urumqi.The enrolling criteria was age above18 years,had a sex with recent 6 month,HIV test result was negative and would be living Urumqi in next one year.In the base line,6 month visit and 12 month visit were conducted 3 times pre test counseling,and testeed HIV/HSV-2 levels.Results Thre hundred and fourty participants who HIV test result negative was observed with 282 person-years.Totally had 8 person seroconversion,HIV incidence rate was 2.84/100 person-years.311 participants who syphilis test result negative was observed with 229 person-years.Totally have 7 person seroconversion in syphilis testing.Syphilis incidence rate was 3.06/100 person-years.300 participants who HSV-2 test result negative was observed in 293 person-years.Totally have 14 person seroconversion in HSV-2 testing.HSV-2 incidence rate was 4.78/100 person-years.Multi-factor Cox regression model analysis showed that past drug use（RR=0.18,95% CI： 0.04-1.00）,and HIV/syphilis of new infections was statistically significant;In 6 month follow-up that whether homosexual commercial sex（RR=0.16,95% CI： 0.05-0.50）,syphilis infection was statistically significant.Conclusion The incidence of HIV and STD is high among MSM in Urumqi,relative methods should be taken promptly,we should take measures to control the spread of HIV/STD epidemic in this population timely.

关 键 词：男男性行为者 队列研究 HIV STD 新发感染率 影响因素 

分 类 号：R512.91[医药卫生—内科学]