不同含锶量羟磷灰石无机骨水泥的制备及其对可注射性的影响  

Preparation and injectability of strontium-containing hydroxyapatite bone cements

作　　者：陈德敏[1] 孙兆瑶[1] 傅远飞[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·生物材料研究测试中心,上海市口腔医学重点实验室,上海200011

出　　处：《功能材料》2012年第22期3135-3138,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(30470480);上海市重点学科建设资助项目(S30206)

摘　　要：采用碳酸钙、碳酸锶和磷酸氢钙为起始原料,经高温固相反应合成制备了不同含锶量(0、5%、10%、15%和20%(原子分数))的羟磷灰石无机骨水泥粉剂,以丙烯酸-衣康酸共聚液和柠檬酸的混合液为骨水泥固化液,探讨不同含锶量对骨水泥可注射性的影响。结果表明,0、5%、10%和15%(原子分数)含锶量试样组的物相结构为含锶的羟磷灰石和α-TCP。20%(原子分数)含锶量试样组的物相结构则为含锶的羟磷灰石和β-TCP,并且不具有水化凝固的特性。随着含锶量的增加,骨水泥的注射性能也变得更好。当粉液比采用1.8g/g时,0、5%、10%和15%(原子分数)试样组骨水泥的可注射率分别达到46%、74%、100%和100%,由此表明锶的掺入可以明显提高羟磷灰石无机骨水泥的可注射性。The powder of different strontium-containing（0,5at%,10at%,15at% and 20at%） hydroxyapatitc bone cements were synthesized from strontium carbonate, calcium carbonate and calcium phosphate dibasic by solid reaction. A mixed solutions that consisted of copolymer of acrylic aeid/itaeonic acid and citric acid were used for setting liquids. The injectability for different strontium-containing bone cements were investigated. The experiment results show that the structure of phases for groups of 0,5at%,10at%,15at% strontium a mount were a series of strontium-containing a-TCP/HA biphases cement by the analyses of XRD and FT-IR, but that of group of 20at% was the strontium-containing 13-TCP/HA biphase, and which had non solidification. The injectability were more good with the increase of strontium amount. When powder to liquids rates was 1. 8g/g, the injectability of groups of 0,5at%, 10at% and 15at% were 46%,74%, 100% and 100% ,respectively.

关 键 词：锶 羟磷灰石 骨水泥 可注射性 

分 类 号：R318.08[医药卫生—生物医学工程]