门诊广泛性焦虑症患者中苯二氮类药物依赖的影响因素分析  

BENZODIAZEPINES(BZDS) DEPENDENCE AND ASSOCIATED FACTORS IN GENERALIZED ANXIETY DISORDER(GAD) OUTPATIENTS

作　　者：王继辉[1] 甘照宇[1] 吴小立[1] 张晋碚[1] 

机构地区：[1]中山大学附属第三医院精神科,广州510630

出　　处：《中国药物依赖性杂志》2012年第5期344-348,共5页Chinese Journal of Drug Dependence

基　　金：广东省科技计划项目(2009B080701080)

摘　　要：目的:研究门诊广泛性焦虑症(generalized anxiety disorder,GAD)患者中苯二氮(benzodiazepines,BZDs)类药物依赖综合征的发生率及影响因素。方法:对141例门诊GAD患者进行回顾性研究,调查BZDs类药物依赖综合征的发生率,并对可能的影响因素进行Logistic回归分析。结果:BZDs类药物依赖综合征发生率为41.8%;首诊时伴有失眠、首诊时联用BZDs、BZDs药物使用时间长是依赖综合征发生的危险因素,OR值(95%CI)分别为8.62(1.25,59.55)、2.39(1.74,3.30)、8.75(1.43,53.69)。结论:GAD患者药物治疗过程中出现BZDs类药物依赖综合征的发生率较高,和首诊处方类型、失眠症状及药物使用时间有关,建议首诊时慎重处方BZDs类药物,特别是对于伴有失眠患者,并且尽量短期使用。Objective:To estimate the prevalence of benzodiazepines dependence and influential factors in generalized anxiety disorder outpatients.Methods:One hundred forty one outpatients with GAD were investigated retrospectively.Results:Among 141 GAD patients,41.8% subjects developed benzodiazepines dependence.BZDs dependence was independently associated with insomnia(OR [95% CI]= 8.62 [1.25,59.55]),BZDs prescription on first visit(OR [95% CI]= 2.39 [1.74,3.30]) and duration of BZDs use(OR [95% CI]=8.75 [1.43,53.69]).Conclusion:A considerable proportion(41.8%) of GAD patients developed BZDs dependence.The factors including the first prescription type,patients' insomnia symptom and the duration of BZDs use were independently related to BZDs dependence.Caution in initiating BZDs prescriptions and no long-term use are recommended,particularly when patients have insomnia problem.

关 键 词：广泛性焦虑症 苯二氮 依赖 

分 类 号：R595.5[医药卫生—内科学]