Periostin基因多态性与苏皖汉族人群冠心病发病的初步研究  

Preliminary research on Periostin gene polymorphisms and incidence of coronary artery disease in Han nationality of Jiangsu and Anhui provinces

作　　者：周学军[1] 纪元[1] 蒋建光[1] 刘志平[1] 王芳芳[1] 丁志坚[1] 

机构地区：[1]南京医科大学附属常州第二人民医院心内科,江苏常州213000

出　　处：《实用临床医药杂志》2012年第17期15-17,24,共4页Journal of Clinical Medicine in Practice

摘　　要：目的研究Periostin(POSTN)基因多态性与苏皖汉族人群冠心病发病的关系。方法采用聚合酶链反应-限制性片段长度多态法检测POSTN基因启动子区位点(SNP A-953T)基因型。观察POSTN基因突变率与冠心病发病的可能关系。结果证实在中国人群POSTN A-953T存在TT基因型。冠心病患者基因型分布:POSTN A-953T(AA型275例,AT型202例,TT型16例)。正常人群基因型分布:POSTN A-953T(AA型368例,AT型266例,TT型31例)。POSTN基因型分布冠心病组与正常人群间差异无显著性意义。结论 POSTN基因多态性与冠心病发病危险未发现明显相关。Objective To explore whether the polymorphisms in Periostin （POSTN） are as- sociated with the risk of coronary artery disease （CAD）. Methods The single nucleotide polymor- phisms （ SNP A-953T） within the promoter region were chosen for further analyses. The possible rela- tionship between POSTN gene polymorphisms and incidence of coronary artery disease were observed. Results In our study, the TT genotype of SNP-A953T was first detected to be valid in the Chinese population, not available in the HAPMAP CHB Project. For the A953T polymorphism, of the 554 ca- ses, 275 homozygotes for the A allele, 202 heterozygotes and 16 homozygotes for the T allele were de- tected, of the 687 controls, 368 homozygotes for the A allele, 266 heterozygotes and 31 homozygotes for the T allele were detected. Genotype distribution of the POSTN was not found to differ significantly in CAD subjects when compared to controls. Conclusion POSTN polymorphisms SNPA -953T are not significantly associated with the risk of CAD in Chinese population of our study.

关 键 词：冠心病 Periostin基因 单核苷酸多态性 血浆 

分 类 号：R541.4[医药卫生—心血管疾病]