醒脑静联合左旋门冬氨酸-鸟氨酸治疗肝硬化合并肝性脑病的疗效分析  

Efficacy analysis of Xingnaojing injection combined with levorotatory aspartic acid-ornithine on hepatocirrhosis complicated with hepaticencephalopathy

作　　者：乔岩[1] 

机构地区：[1]天津市大港油田职工总医院消化内科,天津300280

出　　处：《实用临床医药杂志》2012年第17期99-101,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11220110)

摘　　要：目的探讨醒脑静联合左旋门冬氨酸-鸟氨酸治疗肝硬化合并肝性脑病(HE)的疗效。方法将85例肝硬化合并HE患者随机分为观察组43例及对照组42例,2组均予以常规治疗,并静滴左旋门冬氨酸-鸟氨酸,观察组在此基础上加用醒脑静注射液。比较2组肝功能及血氨变化,数字连接试验(NCT)及数字符号试验(DS)结果,以及总有效率。结果 2组总胆红素(TBiL)、谷丙转氨酶(ALT)、血氨(NH3)、NCT、DS结果均较治疗前显著改善,且观察组改善程度大于对照组;观察组总有效率亦显著高于对照组。结论醒脑静注射液联合左旋门冬氨酸-鸟氨酸治疗肝硬化合并HE与后者单药治疗相比,可显著改善肝功能、NCT、DS,降低血氨,提高总有效率,值得临床推广。Objective To explore the efficacy of Xingnaojing injection combined with lev- orotatory aspartic acid-ornithine on hepatocirrhosis complicated with hepatic encephalopathy （HE）. Methods Eighty-five patients of hepatocirrhosis complicated with HE were divided into observation group （ n = 43） and control group （ n = 42）. Both groups received routine treatment and levorotato- ry aspartic acid-ornithine, and the observation group received additional Xingnaojing injection. The levels of liver function, NH3, NCT, DS and overall response rate were compared. Results After treatment, the levels of TBiL, ALT, NH3, NCT, DS improved significantly, and the improve- ment in the observation group was larger than that in the control group. The overall response rate in the observation group was obviously higher than that in the control group. Conclusion Compared with monotherapy of levorotatory aspartic acid-ornithine, the combination with Xingnaojing injec- tion on hepatocirrhosis complicated with HE can obviously improve liver function, NCT, DS, re- duce the serum NH3, and raise the overall response rate. It＇s worthy of clinical application.

关 键 词：醒脑静 门冬氨酸 鸟氨酸 肝性脑病 肝硬化 

分 类 号：R657.3[医药卫生—外科学]