肺泡巨噬细胞在急性肺损伤中的作用  

Role of alveolar macrophage in acute lung injury

作　　者：朱莹[1] 胥武剑[1] 李强[1] 

机构地区：[1]第二军医大学附属长海医院呼吸内科,上海200433

出　　处：《国际呼吸杂志》2012年第21期1666-1670,共5页International Journal of Respiration

摘　　要：肺泡巨噬细胞作为常驻肺部的主要固有免疫细胞，在急性肺损伤（ALI）的发生、发展以及转归过程中发挥了十分重要的作用。在ALI早期，肺部固有巨噬细胞通过释放趋化因子募集更多的外周巨噬细胞及中性粒细胞至炎症部位，启动肺部炎症反应。随着炎症的进一步发展，肺泡巨噬细胞功能的适度发挥调节中性粒细胞的过度激活从而控制炎症的失控性进展。在ALI晚期，肺泡巨噬细胞再次通过清除凋亡的炎症细胞加速炎症的消退，从而影响ALI的转归及预后。The alveolar macrophage is the main resident natural immune cells in the lung, which plays an important role in the occurrence, development and complete resolution of acute lung injury. In the early stage, the resident alveolar macrophages recruit exudated macrophages and neutrophils by releasing chemokines and start inflammation progress. With the further development of inflammation, the regulation of alveolar macrophage inhibit the excessive activation of neutrophils and control inflammation progress. In the late stage, the alveolar macrophages undergo apoptosis during resolving inflammation, which affect the resolution and prognosis of acute lung injury.

关 键 词：急性肺损伤 肺泡巨噬细胞 凋亡 肺纤维化 

分 类 号：R563.8[医药卫生—呼吸系统]