蒽环类药物治疗弥漫大B细胞淋巴瘤中脑钠肽水平检测的临床意义  

Clinical significance of brain natriuretic peptide level in treatment of diffuse large B-cell lymphoma by anthracycline drugs

作　　者：王晓[1] 常保萍[1] 王瑞丽[2] 阮林海[2] 赵变锋[1] 水会锋[1] 王万里[1] 

机构地区：[1]河南科技大学第二附属医院血液肿瘤科,河南洛阳471000 [2]河南科技大学第一附属医院血液科,河南洛阳471003

出　　处：《新乡医学院学报》2012年第11期859-861,共3页Journal of Xinxiang Medical University

摘　　要：目的通过检测并比较不同蒽环类药物治疗弥漫大B细胞淋巴瘤中血清脑钠肽(BNP)水平,评价血清BNP水平在化学治疗药物对心脏毒性方面检测的临床意义。方法 80例初治的弥漫大B细胞淋巴瘤患者,随机分为2组,环磷酰胺(C)+多柔比星(H)+长春新碱(O)+泼尼松(P)(CHOP)治疗组和环磷酰胺(C)+表柔比星(E)+长春新碱(O)+泼尼松(P)(CEOP)治疗组。检测并比较2组患者治疗前及治疗2、4、6个周期后血清BNP水平。结果CHOP治疗组有效率为70.0%,CEOP治疗组有效率为75.0%,2组有效率比较差异无统计学意义(P>0.05)。治疗4、6个周期后,2组间血清BNP水平比较差异均有统计学意义(P<0.05);2组治疗4、6个周期后血清BNP水平与治疗前比较,差异均有统计学意义(P<0.05)。结论随着蒽环类药物剂量的蓄积,弥漫大B细胞淋巴瘤患者血清BNP水平逐渐升高,提示血清BNP水平在评价心脏毒性的危险分层、指导临床用药中具有重要意义。Objective To evaluate the clinical significance of brain natriuretic peptide （BNP） level on cardiac toxicity in chemotherapy drugs by testing and comparing the levels of serum BNP in different anthracycline drugs on treatment of diffuse large B-cell Lymphoma. Methods Eighty patients with diffuse large B-cell lymphoma who treated initially were randomly di- vided into two groups ：cytoxan （C） ＋ hydroxyldaunorubicin （H） ＋ oncovin （O） ＋ prednisone （P） （CHOP） treatment group and cytoxan （C） ＋ epirubicin （E） ＋ oncovin （O） ＋ prednisone （P） （CEOP） treatment group. The levels of serum BNP be- fore treatment and after treatment for 2,4,6 periods were detected and compared between the two groups. Results The effi- ciencies of CHOP treatment group and CEOP treatment group were 70.0% and 75.0% respectively,there was no statistically significant （P 〉 0.05 ）. After the treatment for 4,6 periods, there were statistically significant in difference of serum BNP levels between the two groups （P 〈 0.05 ） ;and compared with before treatment, respectively, there were statistically significant in both group （ P 〈 0. 05 ）. Conclusion With anthracycline drugs accumulating, serum BNP levels of diffuse large B-cell lymphoma patients rose up gradually ,which denoted that BNP levels has great significance in guiding usage of clinical drugs and in evalu- ating the risk stratification of cardiotoxicity.

关 键 词：淋巴瘤 弥漫大B细胞 蒽环类 脑钠肽 

分 类 号：R551.2[医药卫生—血液循环系统疾病]