氟比洛芬酯预防瑞芬太尼全麻术后躁动的临床观察  

Clinical efficacy of flurbiprofen axetil for prevention of postoperative restlessness under general anaesthesia with remifentanil

作　　者：刘会凤[1] 夏晓琼[1] 罗宏丽[1] 

机构地区：[1]安徽省巢湖市第一人民医院麻醉科,238000

出　　处：《蚌埠医学院学报》2012年第11期1305-1306,1309,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨氟比洛芬酯超前镇痛预防瑞芬太尼全麻患者术后躁动的有效性与安全性。方法:选择全麻手术120例,分为氟比洛芬酯组(F组)和对照组(C组)各60例。F组于手术开始前静脉注射氟比洛芬酯50 mg,C组静脉注射脂肪乳剂5 ml。均选择气管内全麻,术中全部采用瑞芬太尼0.1～0.2μg.kg-1.min-1维持。分别观察2组患者的全麻苏醒时间,拔管时间以及苏醒期躁动情况,并采用视觉模拟评分评价术后镇痛情况。结果:术前使用氟比洛芬酯超前镇痛后,F组苏醒期躁动率为5.0%,明显低于C组的41.7%(P<0.01)。结论:氟比洛芬酯超前镇痛对瑞芬太尼全麻后躁动有较好的预防作用。Objective：To observe investigate the efficacy and safety of preemptive analgesia with flurbiprofen axetil in preventing postoperative restlessness of patients under general anaesthesia with remifentanil. Methods：One hundred and twenty patients under general anaesthesia with remifentanil were evenly divided into two groups（group F and group C）.Group F were intravenously injected with flurbiprofen axetil 50 mg and group C were injected with placebo（fat emulsion） 5 ml before surgery.The anesthesia awaking time,extubation time and postoperative restlessness were observed in the two groups,and the postoperative analgesia was evaluated by visual analogue scale. Results：When flurbiprofen axetil was used as preemptive analgesia,the postoperative restlessness rate was 5.0% in group F,which was obviously lower than the 41.7% in group C（P0.01）. Conclusions：Preemptive analgesia with flurbiprofen axetil can effectively prevent the postoperative restlessness of patients under general anaesthesia with remifentanil.

关 键 词：氟比洛芬酯 超前镇痛 瑞芬太尼 术后躁动 

分 类 号：R971.1[医药卫生—药品]