1999-2011年铜绿假单胞菌临床分布及耐药性分析  

Analysis on distribution and drug resistance of Pseudomonas aeruginosa during 1999-2011

作　　者：李玉强[1] 万忠林 

机构地区：[1]河南省平顶山市第一人民医院,平顶山467000 [2]平高集团有限公司医院

出　　处：《临床医学》2012年第6期39-41,共3页Clinical Medicine

摘　　要：目的了解医院铜绿假单胞菌(PAE)的耐药现状,为临床用药提供依据。方法将医院分离的PAE药敏试验结果,应用WHONET5.5软件进行统计学分析。结果 1999-2007年PAE的耐药率呈上升趋势,2008-2011年则呈下降趋势。除头孢他啶外,其他三代头孢已完全耐药。对PAE较敏感的药物有多粘菌素B、阿米卡星、亚胺培南和头孢他啶。结论 PAE耐药严重,临床要合理应用抗菌药物,医院应加强对PAE的监控。Objective To investigate the distribution and drug resistance status of Pseudomonas aeruginosa （PAE） and to provide reference for clinical treatment in our hospital. Methods The drug susceptibility was tested by Kirby-Bauer method. The data of drug susceptibility test were analyzed by WHONET5.5 software. Results The drug resistance of PAE to most antibi- otics had an increasing trend during 1999 -2007, while had a decreasing trend during 2008 -2011. The resistance rates to the third generation cephalosporins were 100%, except ceftazidime. The highest susceptibility to PAE was polymyxin B, amikacin, imipenem and ceftazidime. Conclusion The drug resistance of PAE is serious. It＇ s very improtant to select antibiotics correctly according to the results of susceptibility test in clinic. Supervision of drug resistance of PAE should be strengthened in hospital.

关 键 词：铜绿假单胞菌 抗菌药物 耐药性 

分 类 号：R446.5[医药卫生—诊断学]