Neuropsychological study of patients with obsessive-compulsive disorder and their parents in China: searching for potential endophenotypes  

作　　者：Bin Li Jin-Hua Sun Tao Li Yan-Chun Yang 

机构地区：[1]Department of Psychiatry, West China Hospital Sichuan University, Chengdu 610041, China [2]Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China

出　　处：《Neuroscience Bulletin》2012年第5期475-482,共8页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation for Distinguished Young Scholars of China (30125014)

摘　　要：Objective The existence of neuropsychological deficits has been implicated in obsessive-compulsive disorder （OCD）, particularly memory, attention, and executive functions. However, few studies have focused on neuropsychological deficits in the relatives of OCD patients. The aim of this study was to investigate cognitive deficits in OCD patients and their parents. Methods Forty patients with OCD, 48 parents of these patients, and 87 healthy controls completed a neuropsychological testing battery. Results Both OCD patients and their parents showed impairments in delayed verbal memory and delayed visual memory. Furthermore, they performed worse than healthy controls in problem-solving ability. Conclusion Our study demonstrated familial aggregation of delayed memory deficits and impaired problem-solving ability, which may be the potential neuropsychological endophenotypes of hereditary susceptibility to OCD.Objective The existence of neuropsychological deficits has been implicated in obsessive-compulsive disorder （OCD）, particularly memory, attention, and executive functions. However, few studies have focused on neuropsychological deficits in the relatives of OCD patients. The aim of this study was to investigate cognitive deficits in OCD patients and their parents. Methods Forty patients with OCD, 48 parents of these patients, and 87 healthy controls completed a neuropsychological testing battery. Results Both OCD patients and their parents showed impairments in delayed verbal memory and delayed visual memory. Furthermore, they performed worse than healthy controls in problem-solving ability. Conclusion Our study demonstrated familial aggregation of delayed memory deficits and impaired problem-solving ability, which may be the potential neuropsychological endophenotypes of hereditary susceptibility to OCD.

关 键 词：obsessive-compulsive disorder neuropsychological tests memory deficits problem-solving ability endophe-notype 

分 类 号：Q42[生物学—神经生物学] B84[生物学—生理学]