原发性干燥综合征伴肺间质损害患者血清中白细胞介素-17水平及其临床意义的研究’  

The level and clinical significance of interieukin-17 in primary Sjogren＇s syndrome with interstitiallung disease

作　　者：时一添[1] 孟祥慧[1] 孙婷婷[1] 田百玲[1] 赵珊[1] 杨娉婷[1] 肖卫国[1] 

机构地区：[1]中国医科大学附属第一医院风湿免疫科,沈阳110001

出　　处：《中华风湿病学杂志》2012年第11期738-740,共3页Chinese Journal of Rheumatology

基　　金：国家自然科学基金（30801204）;辽宁省医学高峰工程建设项目（2010006）

摘　　要：目的探讨原发性干燥综合征（pSS）伴肺间质改变患者血清中白细胞介素（IL）-17水平及其临床意义。方法筛选单纯涎腺和（或）泪腺受累pSS患者25例，仅伴肺间质损害pSS患者28例。15名健康献血者为健康对照组。采用酶联免疫吸附试验法测定患者及健康对照者血清IL-17水平，同时记录患者相关临床及实验室资料。采用方差分析、最小显著差异法和Pearson相关分析检验进行统计分析。结果3组血清中IL-17水平差异有统计学意义（F=2．504，P=-0．000）。伴肺间质损害pSS患者血清IL-17水平（212±77）Dg／ml较单纯涎腺和（或）泪腺受累患者（111±25）pg／ml明显升高（P〈O．05），而单纯涎腺和（或）泪腺受累患者血清IL-17水平与健康对照相比差异无统计学意义（P〉0．05）。结论IL-17可能参与干燥综合征肺间质损害过程。Objective To investigate the level of IL-17 and its clinical significance in patients with primary Sjtigren＇s syndrome （pSS） complicated with interstitial lung disease （ILD）. Methods IL-17 levels were detected by enzyme linked immunosorbent assay （ELISA） in 53 untreated patients with pSS （25 patients with only lacriminal and/or salivary gland involvement, 28 with only interstitial lung disease involvement） and 15 healthy controls. The related clinical and laboratory data were recorded. ANOVA, LSD test and Pearson test were used for statistical analysis. Results There were significant differences between the 3 groups（F=22.504,P=-0.000）. The mean concentration of sera IL-17 in the patients with ILD was significantly higher than in patients with only lacriminal or salivary gland involvement （P〈0.05）. There was no difference in the levels of sera IL-17 between the patients with only lacriminal and/or salivary gland involvement and healthy controls （P〉0.05）. Conclusion Our results show that patients with pSS concomitant with ILD have high serum IL-17 levels ,which highlight the role of IL-17 in SjSgren＇s syndrome interstitial lung injury.

关 键 词：干燥综合征 肺疾病 间质性 白细胞介素-17 

分 类 号：R593.2[医药卫生—内科学]