非胰岛素依赖型糖尿病体内氧化代谢改变及与高血压的关系  

CHANGE OF OXIDATION METABOLISM OF NIDDM AND RELATIONSHIP BETWEEN NIDDM AND HYPERTENSION

作　　者：刘和俊[1] 李芹[1] 

机构地区：[1]安徽医科大学附属医院心内科,安徽合肥230022

出　　处：《医师进修杂志》2000年第5期26-28,共3页Journal of Postgraduates of Medicine

摘　　要：目的：评价氧化损伤及抗氧化酶活性对非胰岛素依赖型糖尿病即Ⅱ型糖尿病（ＮＩＤＤＭ）及其伴发高血压（ＨＴ）的影响。方法：采用鲁米诺依赖的中性粒细胞化学发光法，对１３６例ＮＩＤＤＭ患者（其中７０例不伴有ＨＴ，６６例伴有ＨＴ）及３０例年龄匹配的健康对照者，检测其外周血中性粒细胞产生氧自由基（ＯＦＲ）的水平。采用化学定量法。Objectives:Oxidative stress is believed to play an important role in the development of hypertension associates with diabetes mellitus in animal models.To test this hypothesis in humans,To evaluate the markers of polymorphonuclear leukocyte oxygen free radical (OFR) production,lipid peroxidation and defenses against oxidative stress in NIDDM patients with and without hypertension.Methods:A convenient and senstive method for estimation of neutrophil OFR production was assayed by polymorphonuclear leukocyte chemiluminescence (PMN-CL).The parameters of PMN-CL have been measured,the plasma malondialdehyde(MDA) concentration,and the plasma activities of superoxide dismutase(SOD) and glulathione peroxidase (GSHPx) in 136 NIDDM patients (70 without hypertension and 66 with hypertension) and 30 age-matched healthy subjects.Results:Patients with hypertension showed significantly increased PMN-CL parameters as peak value,integration,and phagocytic index compared to diabetics without hypertension and healthy controls ,(P<0.01,respectively).And the plasma MDS concentration,increased in patients with hypertension compared with that in diabetics without hypertension and healthy controls,P<0.01.respectively.The PMN-CL peak value correlated best with plasma MDA concentration (r=0.748 6,P<0.01,n=66) and negatively correlated with the plasma activity of SOD (r=-0.6471,P<0.05,n=66).Conclusions:These data confirm that the oxidative stress exists in NIDDM and suggest that diabetic patients with hypertension have an increase in this oxidative stress which may have pathogenetic implications.

关 键 词：糖尿病 高血压 氧化损伤 NIDDM 丙二醛 SOD 测定 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]