幽门螺杆菌及其脂多糖与刺猬蛋白信号通路关系的研究进展  

Research Progress of the Relationship between Helicobacter Pylori Lipopolysaccharide and the Sonic Hedgehog Signaling Pathway

作　　者：陈菲菲[1] 张军[1] 

机构地区：[1]南京医科大学附属南京医院南京市第一医院消化内科,南京210006

出　　处：《医学综述》2012年第21期3561-3564,共4页Medical Recapitulate

摘　　要：近年来,多项研究表明Shh信号通路与消化道肿瘤密切相关,并发现幽门螺旋杆菌(Hp)感染对Shh信号通路的表达有影响。Hp脂多糖在Hp相关疾病中发挥着重要作用,亦可能影响Shh信号通路的表达,但它们之间具体作用机制尚需进一步明确。现主要对Hp及其脂多糖的功能,Shh信号通路构成及其功能,Hp及其脂多糖与Shh信号通路间的关系予以综述。Recent studies indicate that Sonic hedgehog（Shh）signaling pathway has been closely linked to gastrointestinal tumors,and some studies show that Helicobacter pylori（Hp）infection has an effect on the expression of Shh signaling pathway.Hp lipopolysaccharide plays an important role in Hp related diseases,which may also affect the expression of Shh signaling pathway,but the specific mechanism need to be clarified.Here is to make a review on the function of Hp and its lipopolysaccharide,the constitution and function of Shh signaling pathway,and the relationship between the two.

关 键 词：幽门螺杆菌 脂多糖 刺猬蛋白信号通路 

分 类 号：R379.9[医药卫生—病原生物学]