代谢手术治疗2型糖尿病相关机制研究述略  

Mechanisms of Metabolic Surgery in Treatment of Type 2 Diabetes

作　　者：孙若飞[1,2] 王昆华[1,2] 

机构地区：[1]昆明医科大学附属昆华医院 [2]云南省第一人民医院云南省肠外肠内营养研究中心普外一科,昆明650032

出　　处：《医学综述》2012年第21期3637-3640,共4页Medical Recapitulate

基　　金：昆明医科大学研究生创新基金资助;云南省卫生科技计划项目资助(2011WS0008)

摘　　要：糖尿病是严重威胁人类健康的代谢性疾病,全球发病率有逐年增高的趋势。Roux-en-Y胃转流术和胆胰转流术治疗2型糖尿病的疗效确切,但机制不清。大量的研究表明,热量吸收减少和体质量减轻并非是2型糖尿病在接受Roux-en-Y胃转流术和胆胰转流术术后血糖缓解的直接原因,而更可能与肠道激素、脂肪细胞因子、炎性介质等的作用有关,现就近年来相关机制的研究现状和进展予以综述。Diabetes mellitus is a metabolic disease seriously threatening human health.The worldwide prevalence of diabetes has been already increasing year by year.Type 2 diabetes can be treated by Roux-en-Y gastric bypass and biliopancrtic diversion,but the mechanism is unclear.A large number of studies have shown that the heat absorption reduction and body weight loss may not be the direct cause of postoperative blood glucose reduction;instead,it is more likely associated with intestinal hormones,adipocytokines,and inflammatory mediators.Here is to make a review on its possible mechanism from recent researches.

关 键 词：胃转流术 2型糖尿病 胆胰转流术 

分 类 号：R585[医药卫生—内分泌] R374[医药卫生—内科学]