有机锗与鲨肝醇对苯中毒小鼠升白细胞作用的比较研究  

Compared Study of Treatmental Effects of Ge-132 and Batiolum on Decrease of WBC Counts in Bezene-Exposed Mice

作　　者：张强[1] 张凯[1] 林立[1] 

机构地区：[1]济宁医学院职业卫生与环境医学研究所,272013

出　　处：《中国公共卫生》2000年第5期419-420,共2页Chinese Journal of Public Health

基　　金：山东省教委基金

摘　　要：评价有机锗 (Ge -13 2 )对苯中毒小鼠白细胞降低的治疗作用在制备动物模型的基础上 ,将符合诊断标准的动物给予鲨肝醇和不同剂量有机锗治疗。 4周后 ,对其外周白细胞总数、分类、血红蛋白骨髓及脏器系数进行检测。结果显示 :Ge-13 2对人工诱导苯中毒所致的外周白细胞降低有一定的治疗作用 ,它优于鳖肝醇 ,以 5 0 0mg/kg剂量组治疗效果最佳。提示有机锗治疗苯中毒所致的白细胞减少症比鲨肝醇更有效。To evaluate reatmental effects of Ge-132 and Batiolum on decrease of WBC counts in bezene-exposedmice.The mice conforming to diagnotic carteria were treated by Ge-132 and Batiolum indifferent dosdage.under the base of animal model.The peripheral WBC counts,WBC classification,heatoglobin level,bone marrow cell and dorgan coefficient were checked after four weeksd.Ge-132 has hematopoiesis effect in bezene-exposed mice and is better than Bdatiolum espeilly in 500mg/kg group.Ge-132 is better than Batiolum in treating decrease of WBC in bezene-exposed mice.

关 键 词：GE-132 鲨肝醇 苯中毒 有机锗 白细胞减少 治疗 

分 类 号：R598.120.5[医药卫生—内科学] R977.9[医药卫生—临床医学]