瑶药血党化学成分的研究  

Chemical constituents of Ardisia punctata

作　　者：马长福[1,2] 罗明[1] 林丽美[3] 李春[1,4] 王智民[1,4] 程翼宇[2] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]天津中医药大学,天津300193 [3]湖南中医药大学,湖南长沙410208 [4]中药质量控制技术国家工程实验室,北京100700

出　　处：《中国中药杂志》2012年第22期3422-3425,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09301-005;2009ZX09308-003)

摘　　要：目的:研究血党的化学成分,寻找结构新颖的先导化合物。方法:应用正相、反相硅胶柱色谱,Sephadex LH-20凝胶柱色谱及高压制备HPLC对血党95%乙醇提取物进行分离、纯化,采用NMR,MS等波谱方法进行结构鉴定。结果:从血党95%乙醇提取物中共分离鉴定了8个化合物,分别是6-甲氧基-8-羟基-苯丙酸丁酯-5-O-β-D-葡萄糖苷(1),aridisiacrispin B(2),ardisicrenoside A(3),邻苯二甲酸二丁酯(4),岩白菜素(5),槲皮素-3-O-α-L-鼠李糖苷(6),3-甲氧基-4-乙酰氧基-5-十三烷基苯酚(7)和belamcandaquinone C(8)。结论:化合物1为新化合物,化合物4和6为首次从该植物中分离得到。Objective： To study chemical constituents of Ardisia punctata,in order to find pioneering compounds. Method： 95% ethanol extracts of A. punctata was separated and purified by using normal phase silica gel column chromatographies, Sephadex LH-20 gel column chromatography and high-pressure preparative HPLC, and their structures were identified by such spectroscopic tech- niques as NMR and MS. Result： Eight compounds were separated from 95% ethanol extract of A. punctata and identified as 6-me- thoxy-8-hydroxy-benzoic acid butylester-5-O-β-D-glucoside （ 1 ）, aridisiacrispin B （ 2 ）, ardisicrenoside A （ 3 ）, dibutyl phthalate （ 4 ）, ber- genin （ 5 ） , quercetin-3 -O-α-L-rhamnoside （ 6 ）, 3 -methoxy-4-acetoxy-6-tridecyl-phenol （ 7 ） and belamcandaquinone C （ 8 ）. Conclusion ： Compound 1 was a new compound, and compounds 4 and 6 were separated from this plant for the first time.

关 键 词：血党 化学成分 酚酸类化合物 

分 类 号：R284[医药卫生—中药学]