香血藤中倍半萜类化学成分研究  

Sesquiterpenes from stem of Schisandra glaucescens

作　　者：张培培[1] 高莎莎[1] 张甜甜[1] 陈家春[1] 段宏泉[2] 方进波[1] 

机构地区：[1]华中科技大学同济医学院药学院天然药物化学与资源评价湖北省重点实验室,湖北武汉430030 [2]天津医科大学药学院,天津300070

出　　处：《中国中药杂志》2012年第22期3426-3429,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31000150);华中科技大学自主创新基金项目(2012QN006)

摘　　要：目的:研究香血藤Schisandra glaucescens的化学成分。方法:以硅胶柱、凝胶柱色谱分离,制备HPLC纯化,采用MS,NMR等波谱方法进行结构鉴定。结果:从石油醚部位分离得到12个化合物:t-杜松醇(t-cadinol,1),α-杜松醇(α-cadinol,2),榧树醇(torreyol,3),(+)-ent-epicubenol(4),ent-T-muurolol(5),(-)-15-hydroxycalamenene(6),(-)-cubebol(7),4-epi-cubebol(8),石竹烯醇-I(caryophyllenol-I,9),石竹烯醇-II(caryophyllenol-II,10),oxyphyllenodiols A(11),caryolane-1,9β-diol(12)。结论:化合物4,6～12均首次从该属植物中分得,化合物1～12均首次从该植物中分得。Objective： To study the chemical constituents from Schisandra glaucescens. Method： The chemical constituents were separated and purifed with silica gel, gel column chromatography preparative H_PLC, and their structures were identified by such spectra/ methods as MS and NMR. Result ： Twelve compounds were separated from petroleum ether fractions, and identified as t-cadinol （ 1 ）, α-cadi- nol （2）, torreyol （3）, （ ＋ ）-ent-epicubenol （4）, ent-T-muurolol （5）, （ - ）-15-hydroxycalamenene （6）, （ - ）-cubebol （7）, 4-epi-cube- bol （8）, caryophyllenol-I （9）, caryophyllenol-II （10）, oxyphyllenodiols A （11）, caryolane-1,9β-diol （12）. Conclusion： Compounds 4, 6- 12 were separated from the genus for the first time, while compounds 1-12 were separated from this olant for the first time.

关 键 词：香血藤 杜松烷型 荜澄茄烷型 石竹烷型 caryolane型 倍半萜 

分 类 号：R284[医药卫生—中药学]