脂肪细胞因子Chemerin在妊娠期高血压疾病中的水平变化  

Change of adipocytokine Chemerin level in hypertensive disorder complicating pregnancy

作　　者：肖玲[1] 王心[1] 尚丽新[1] 霍晓溪[1] 

机构地区：[1]北京军区总医院妇产科,北京100700

出　　处：《中国妇幼保健》2012年第32期5165-5168,共4页Maternal and Child Health Care of China

摘　　要：目的:研究妊娠期高血压疾病(HDCP)患者血浆中Chemerin的含量,以探讨其在HDCP发病机制中的作用,判断是否可作为HDCP一个新的预测标志物。方法:采用酶联免疫吸附法(ELISA)分别检测40例正常孕妇(对照组)和42例HDCP患者(试验组,其中轻度子痫前期17例、重度子痫11例、妊娠期高血压14例)中的血浆Chemerin水平,同时测定受试者的体质量指数(BMI)、血压,检测血糖、血脂、胰岛素等指标,比较两组的差异性。结果:妊娠期高血压疾病组(25.0±4.3)pg/ml血浆Chemerin含量明显高于对照组(9.5±3.2)pg/ml,差异有统计学意义(P<0.05),且重度子痫前期组(30.5±4.4)pg/ml明显高于轻度子痫前期(25.6±4.6)pg/ml和妊娠期高血压组(17.8±4.0)pg/ml(P<0.05);轻度子痫前期组高于妊娠期高血压组(P<0.05)。结论:在妊娠期高血压疾病组中Chemerin浓度是上升的,可作为识别可能有HDCP高危风险的孕妇的一个有价值的检测因子。Objective： To research the content of Chemerin in plasma samples of patients with hypertensive disorder complicating pregnancy （HDCP）, explore the effect of Chemerin in pathogenesis of HDCP, and judge whether Chemerin can be used as a new marker to predict HDCP. Methods： ELISA was used to detect the plasma levels of Chemerin in 40 normal pregnant women （control group） and 42 HDCP patients （experimental group, including 17 patients with mild preeclampsia, 11 patients with severe preeclampsia, and 14 patients with gestational hypertension） ; at the same time, the indexes including body mass index （ BMI）, blood pressure, blood glucose, blood lip id, and insulin were detected, then the differences were compared between the two groups. Results ： The plasma level of Chemerin in experi- mental group was （25.0 ±4. 3） pg/ml, which was statistically significantly higher than that in control group [ （9. 5 ±3.2） pg/ml3 （P 〈 0. 05 ） . The plasma level of Chemerin in severe preeclampsia group was （ 30. 5 ±4.4 ） pg/ml, which was statistically significantly higher than those in mild preeclampsia group [ （25.6±4. 6） pg/ml3 and gestational hypertension group [ （17.8±4. 0） pg/ml3 （P〈0. 05） . The plasma level of Chemerin in mild preeclampsia group was statistically significantly higher than that in gestational hypertension group （ P 〈 0. 05 ） . Conclusion ： The concentration of Chemerin in HDCP patients increases, which can be used as a valuable detection marker for identifying the pregnant women with high risk of HDCP.

关 键 词：妊娠期高血压疾病 CHEMERIN 脂肪细胞因子 子痫前期 

分 类 号：R714.246[医药卫生—妇产科学]