血清Scy-c、尿β2-MG对妊娠期高血压疾病早期肾损伤的诊断价值  

Diagnostic value of serum Scy-C,urinary β2-MG in early renal damage of hypertensive disorder complicating pregnancy

作　　者：金全芳[1] 锁丙荣[1] 周坤苗[1] 岳艳[1] 

机构地区：[1]湖北医学院附属十堰市人民医院妇产科,442000

出　　处：《中国妇幼保健》2012年第32期5210-5212,共3页Maternal and Child Health Care of China

摘　　要：目的:探究妊娠期高血压疾病患者血清胱抑素c(Scy-c)及尿β2微球蛋白(β2-MG)对早期肾损伤诊断的临床应用价值。方法:选择124例妊娠期高血压患者为研究对象,其中68例肾功能损伤患者为观察组1,56例肾功能正常患者为观察组2,并以48例健康体检孕妇为对照组,观察3组别血清Scy-c及尿β2-MG浓度,并研究血清Scy-c及尿β2-MG浓度与妊娠期高血压严重程度的关系。结果:观察组1、2及对照组Scy-c、尿β2-MG经方差分析差异均有统计学意义(P<0.05),SNK法两两比较各组间Scy-c、尿β2-MG差异也有统计学意义(P<0.05),在对照组、观察组2、观察组1 3组中血清Scy-c、尿β2-MG依次升高。结论:血清Scy-c、尿β2-MG对妊娠期高血压疾病患者早期肾功能受损有良好的监测作用。Objective： To explore the clinical value of serum cystatin C （ Scy - c ） and urinary β2 microglobulin （ β 2 - MG ） in early diagnosis of renal injury in patients with hypertensive disorder complicating pregnancy. Methods： A total of 124 PIH patients were taken as observation group, including 68 cases of renal injury as observation group 1, 56 cases of patients with normal renal function as observation group 2, and 48 cases of healthy pregnant women as control group Serum Scy- c and urine β2 - MG were compared in the three groups, and studied the relationship between Scy- c, urine β2 - MG and the severity of hypertension of pregnancy. Results： There were significant differences with Scy- c, urinary β2 - MG among observation group 1, observation group 2 and control group by analysis of variance. there was a statistically significant difference in each group by SNK. Scy- c, urine 132 - MG were increased in control group, observation group 2 and observation group 1 by order. Conclusion ： Serum Scy- c, β2 - MG have good testing effect on early renal impairment in patients with hypertensive disorder complicating pregnancy.

关 键 词：胱抑素C 尿Β2微球蛋白 妊娠期高血压疾病 肾功能损伤 

分 类 号：R714.246[医药卫生—妇产科学]