芪胶膏的质量控制  

Study on the quality standard of Qijiao Gao

作　　者：张燕 文永兰[2] 陈瑾歆[3] 曹阳 黄彬 韩平 

机构地区：[1]南充市中心医院,四川南充637000 [2]四川省中西医结合医院,四川成都610072 [3]川北医学院生物化学教研室,四川南充637000 [4]南充市食品药品检验所,四川南充637000

出　　处：《中国医院药学杂志》2012年第21期1731-1734,共4页Chinese Journal of Hospital Pharmacy

基　　金：四川省中医药管理局科技立项课题(编号:2010-76)

摘　　要：目的:建立中药芪胶膏的质量标准。方法:采用TCL法对制剂中黄芪和三七进行定性鉴别,采用HPLC-ELSD法测定黄芪甲苷的含量。结果:TCL鉴别色谱特征斑点明显。黄芪甲苷进样量在1.90464～13.9674μg范围内时,质量与峰面积积分值呈良好的线性关系(r=0.9991,n=6),平均加样回收率为98.52%,RSD=3.7%(n=6)。结论:所建立的TLC和HPLC-ELSD法专属性强,重复性好,可用于芪胶膏的质量控制。OBJECTIVE To establish the quality standard of Qijiao Gao.METHODS The qualitative identifications of Astragalus mongholicus and Pseudo-ginseng were carried out by TLC,and the content of astragaloside was determined by HPLC.RESULTS The developed TLC spots were quite clear.The linearity was from 1.904 64 to 13.967 4 μg for astragaloside by HPLC,and the average recovery was 98.52% for astragaloside with RSD of 3.7%（n=6）.CONCLUSION The methods of established TLC and HPLC are reliable,accurate,specific,reproducible,and suitable for the quality control of Qijiao Gao.

关 键 词：芪胶膏 黄芪甲苷 黄芪 三七 质量控制 

分 类 号：R94[医药卫生—药剂学]