食管鳞癌的中医证候聚类分析  

Cluster Analysis on Chinese Medicine Syndromes of Esophageal Squamous Cell Carcinoma

作　　者：司富春[1] 岳静宇[1] 

机构地区：[1]河南中医学院中医药分子生物学实验室,河南省郑州市金水路1号450008

出　　处：《中医杂志》2012年第22期1944-1947,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30873220;30973698);河南省科技创新团队项目(2010-29);郑州市科技创新团队项目(10CXTD145)

摘　　要：目的用聚类分析法探讨食管鳞癌的中医证候规律。方法采用临床调查表的方法,记录80例食管鳞癌患者的一般信息、主诉和四诊信息,建立80例患者的个人基本信息和中医证候信息条目数据库,并对其中医症状进行系统聚类分析。结果纳入统计分析的食管鳞癌中医症状为74个,出现频率较多的是吞咽固体食物困难、面色萎黄、食欲减退、胸膈闷胀、薄白苔、脉滑、弦等。聚类分析得出痰气交阻证、气虚阳微证、津亏热结证、瘀血内结证4类证候。结论聚类分析可帮助进行食管鳞癌中医证候分类及初步确定证候诊断要点,为中医辨证论治食管鳞癌提供理论依据。Objective To explore Chinese medicine syndrome rule of esophageal squamous cell carcinoma with cluster analy- sis. Methods The clinical data of 80 esophageal squamous cell carcinoma patients was recorded such as general information, chief complaint and four methods of diagnostic information with clinical questionnaire. The basic personal information and Chi- nese medicine syndrome entry database was established. The clinical data was analyzed with hierarchical cluster method. Re- sults Seventy-four symptoms of esophageal squamous cell carcinoma were included and the frequent symptoms were difficult deglutition of solid food, sallow complexion, poor appetite, stuffiness and expansion of diaphragm, thin white tongue fur, and slippery and stringy pulse. Four kinds of syndrome were certified to have the best dispersibility through cluster analysis, i.e. stagnation of phlegm and qi, deficiency of qi and yang, liquid depletion with heat bind, and stagnation of static blood. Conclu- sion Hierarchical cluster analysis could contribute to classifying Chinese medicine syndrome, initially identifying syndrome di- agnosis point and providing theoretical basis to Chinese medicine treatment for esophageal squamous cell carcinoma.

关 键 词：食管癌 鳞癌 证候 聚类分析 

分 类 号：R273[医药卫生—中西医结合] R735.1[医药卫生—中医肿瘤科]