抗菌素痢菌净的电化学分析  

Study on electrochemical analysis of maquinox in drug

作　　者：陈立新[1] 周原[1] 李心恬[2] 方红[2] 

机构地区：[1]湖南工程学院化学化工学院,湖南湘潭411104 [2]深圳出入境检验检疫局工业品中心,广东深圳518045

出　　处：《化学研究与应用》2012年第11期1647-1651,共5页Chemical Research and Application

基　　金：湖南省教育厅科研基金项目(10C0555)资助

摘　　要：采用循环伏安法(CV)、差分脉冲伏安法(DPV)和方波伏安法(SWV)在玻碳电极(GCE)上对痢菌净进行了电化学研究。实验表明:在pH=6.6的B-R缓冲底液中,痢菌净在-0.85伏左右有一个明显的可逆氧化还原峰,考察了不同底液及pH值、扫描速度、富集时间和静止时间的影响。DPV法其线性范围为2.0×10-6mol/L～2.0×10-3mol/L,检出限为5.0×10-8mol/L;SWV法其线性范围为2.0×10-6mol/L～1.0×10-3mol/L,检出限为2.0×10-8mol/L。并对痢菌净的电极反应机理进行了初步探讨,该方法操作简单、灵敏,可用于实际药品测定。Cyclic voltammetry, differential-pulse stripping voltammetry, and square wave voltammetry were used to investigate the electrochemical behavior of maquinox at a glassy carbon electrode and a new method for detection of maquinox was established. The maquinox showed a sensitive reductive peak at-0. 8 5V（ vs. SCE）using cyclic vohammetry in a B-R solution. The impact of buffer solution, pH, accumulation time and scan rate were discussed. The peak current was linear to the concentration of maquinox ranging from 2.0×10^-6 mol/L-2. 0×10^-3 mol/L with a detection limit of 5.0×10^-8 mol/L by DPV,and ranging from 2. 0×10^-6 mol/L-1.0×10^-3 mol/L with a detection limit of 2.0×10^-8 mol/L by SWV. The determination of maquinox has been performed and the possible mechanism for the electrode process was also proposed.

关 键 词：痢菌净 循环伏安法 差分脉冲伏安法 方波伏安法 玻碳电极 

分 类 号：O657.1[理学—分析化学]