苯妥英钠血药浓度监测中的中毒影响因素分析  

Analysis of Toxicity Factors in Blood Concentration Monitoring of Phenytoin

作　　者：董超[1] 王来成[1] 吕冬梅[1] 

机构地区：[1]徐州医学院附属医院药剂科,江苏徐州221006

出　　处：《中国药房》2012年第44期4185-4186,共2页China Pharmacy

摘　　要：目的:为临床合理应用苯妥英钠,防止其中毒的发生提供参考。方法:收集我院门诊及住院患者苯妥英钠血药浓度监测数据,总结发现的中毒案例,对其中毒影响因素进行分析。结果:苯妥英钠中毒的发生存在个体差异,通常其血药浓度超过20μg.mL-1时极易引起中毒。中毒症状与其血药浓度有密切联系,而其血药浓度的异常又与剂量、制剂生物利用度、药物相互作用及患者生理、病理等情况相关。结论:应用苯妥英钠须在血药浓度监测下实施个体化给药方案,并应与临床症状相结合,及时调整方案,才能有效保证患者的用药安全。OBJECTIVE：To provide reference for rational use of phenytoin in the clinic to inhibit the occurrence of toxicosis.METHODS：The data of blood concentration monitoring of phenytoin were collected from outpatients and inpatients of our hospital.The toxic cases were summarized and the influential factors of toxicity were analyzed.RESULTS：The toxicity induced by phenytoin had individual difference.Intoxication occurred extremely often in patients whose blood concentration of phenytoin were over 20 μg·mL-1.Toxicity symptom was closely correlated with blood concentration,while abnormal concentration was associated with dosage,bioavailability,drug interactions,physiological and pathological conditions of patients,and so on.CONCLUSION：It is necessary to give individual dosage regimen under the serum concentration monitoring,so that the safe and effective use of drug can be ensured.

关 键 词：苯妥英钠 血药浓度监测 中毒 影响因素 分析 

分 类 号：R971.6[医药卫生—药品]