上运动神经元损伤后脊髓前角运动神经元中降钙素基因相关肽的变化  

Change of calcitonin gene related peptide in spinal motoneuron after upper motoneuron injury

作　　者：王庚[1] 吴新民[1] 赵国立[1] 刘钢[1] 

机构地区：[1]北京医科大学第一医院麻醉科,100034

出　　处：《中华麻醉学杂志》2000年第5期283-285,共3页Chinese Journal of Anesthesiology

摘　　要：目的　观察上运动神经元损伤后大鼠脊髓前角运动神经元中降钙素基因相关肽(CGRP)的变化。方法　选用 36只成年雄性Wistar大鼠 ,于下胸段行脊髓横断术 ,分别于术后 0、1、2、4、7、14d取出腰段脊髓并分为腹侧和背侧 ,用放免方法测定腹侧脊髓中CGRP的含量。结果　大鼠脊髓前角CGRP的含量自术后第 2天开始显著降低 ,最低值出现在术后第 2天 ,此后维持在这一低水平。Objective To observe the changes of calcitonin gene related peptide (CGRP) in rat spinal motoneuron after upper motoneuron injury. Methods Thirty six adult male Wistar rats were selected. Spinal cord transection was made at the lower thoracic segment. The lumbar regions of spinal cord were removed immediately, 1, 2, 4, 7 and 14 days after surgery to be divided into dorsal and ventral sections. The content of CGRP in ventral section was detected using radioimmunoassay method.Results The level of CGRP in spinal motoneuron of the lumbar region was decreased significantly after transection of spinal cord, reached the lowest level on the 2nd day after surgery and then maintained at the low level.Conclusions The upper motoneuron injury can result in the decrease of CGRP content in spinal motoneuron.

关 键 词：降钙素基因相关肽 运运神经元 上运动神经元损伤 

分 类 号：R651[医药卫生—外科学]