生藤正丁醇部位化学成分  

Chemical Constituents of n-butanol Extract of Stelmatocrypton khasianum

作　　者：莫小宇[1] 麦景标[2] 

机构地区：[1]中山市陈星海医院,广东中山528415 [2]广东三才石岐制药有限公司,广东中山528415

出　　处：《中国实验方剂学杂志》2012年第22期170-172,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究生藤中正丁醇部位的化学成分。方法:采用硅胶柱色谱、HP-20和Sephadex LH-20等分离手段对正丁醇萃取部分进行分离纯化,通过波谱数据分析(1H-NMR,13C-NMR)进行结构鉴定。结果:从正丁醇萃取部分分离6个化合物。分别鉴定为孕甾-4-烯-3,20-二酮(1),3β-羟基-5β-孕甾-20-酮(2),3α-羟基-5β-孕甾-20-酮(3),2β-羟基柳珊瑚酸甲酯(4),suberosanone(5)。结论:上述化合物均为首次从该植物中分离得到。Objective： To study the chemical constituents of the n-butanol extract of Stelmatocrypton khasianum. Method： The n-butanol extract was isolated and purified by silica gel column chromatography, HP-20 and Sephadex LH-20. Their chemical structures were elucidated by spectral data （1H-NMR,13 C-NMR）. Result： Five compounds were isolated from the n-butanol extract. They were identified as pregn-4-ene-3, 20-dione （1）, 3/3, 5B-pregn-20-one-3-ol （2）, 3a-hydroxy-5/3-pregnan-20-one （3）, 2B-hydroxy subergorgic acid methyl ester （4）, suberosanoe （5）. Conclusion： All compounds were isolated from this plant for the first time.

关 键 词：萝藦科 生藤 正丁醇部位 化学成分 

分 类 号：R284.1[医药卫生—中药学]