养正消积胶囊对胃癌组织PCNA,p53蛋白,VEGF表达的影响  

Influence of Yangzheng Xiaoji Capsule on Expressions of PCNA,P53 and VEGF in Gastric Cancer

作　　者：崔兴俊[1] 洪艳艳[1] 毕学杰[1] 陈江红[1] 

机构地区：[1]河北以岭医院肿瘤科,石家庄050091

出　　处：《中国实验方剂学杂志》2012年第22期304-306,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省中医药管理局中医药;中西医结合科研计划项目(2008067)

摘　　要：目的:探讨养正消积胶囊对胃癌组织增殖细胞核抗原(PCNA),p53蛋白,血管内皮生长因子(VEGF)表达的影响。方法:治疗组运用养正消积胶囊联合化疗,对照组单纯化疗,用药6个月,治疗前后均以免疫组化S-P法进行PCNA,p53蛋白,VEGF的检测。结果:两组PCNA,p53,VEGF的表达均明显降低(P<0.01),治疗后治疗组PCNA,p53,VEGF分别为(33.16±12.6)%,(41.35±11.4)%,(42.16±13.61)%,对照组PCNA,p53,VEGF分别为(63.20±15.3)%,(59.15±11.9)%,(63.19±12.47)%,两组相比有统计学差异(P<0.01),治疗组改善优于对照组。结论:养正消积胶囊能明显抑制PCNA,p53蛋白,VEGF表达,进一步阻止逆转胃黏膜上皮的恶性表型,起到抗癌作用。Objective： To investigate the influence of Yangzheng Xiaoji capsule （YXC） on expressions of Proliferating Cell Nuclear Antigen （PCNA） , P53 protein and vascular endothelial growth factor （VEGF） in gastric cancer tissue. Method： Treatment group was treated by YXC combined with chemotherapy for 6 months. The control group was simply treated by chemotherapy for 6 months. The expressions of PCNA, p53 protein and VEGF were determined by s-p dying, and the data were analyzed by statistics. Result： The expressions of PCNA, P53 Protein and VEGF in the treatment group were lowered compared with those in the controls. They were （33.16±12.6）%, （41.35±11.4）%, （42. 16±13.61）% in the treatment group, compared with （63.20±15.3）%, （59. 15 ± 11.9）% , （63.19 ± 12.47）% in the controls （P 〈0.01 ）. Conclusion： YXC inhibits expressions of PCNA, P53 protein and VEGF effectively, and so restrains the malignant appearance of stomach mucosal.

关 键 词：养正消积胶囊 胃癌 PCNA P53蛋白 VEGF 

分 类 号：R287[医药卫生—中药学]