便秘动物模型的研究进展  

Advances of Pharmacological Researches in Constipation Animal Model

作　　者：刘井如[1,2] 季宇彬[1] 陈明苍[2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心药物研究所博士后科研工作站,哈尔滨150076 [2]中国科学院上海药物研究所,上海201203

出　　处：《中国实验方剂学杂志》2012年第22期353-356,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项(2009ZX09301-001)

摘　　要：对便秘动物模型的造模方法进行全面分析和归纳。以便秘、动物模型等关键词,检索了中国学术期刊网络出版总库、Springer期刊数据库,得到相关文献86篇,通过甄别、遴选,采纳24篇为参考文献。总结了小鼠、大鼠、家兔、猕猴、雪貂便秘模型的造模方法及每种方法的特点和适用范围。便秘动物的造模方法多样,但便秘模型的制作和观测指标缺乏深度,有待充分利用现代生化、分子、细胞等检测技术深入探寻便秘机制,使便秘模型的设计思路与临床便秘的病机相符,力求找到评价特定便秘模型成功的标准,以利于便秘动物模型的创新性研究和通便药物的研发。The methods of building constipation models were analyzed and summarized completely. With constipation, animal models as key words, China Academic Journal Network Publishing Database and Springer Link were retrieved. Relevant 86 references were get. 24 articles for reference were adopted through screening. This paper reviewed the methods of building constipation models in the rats, mice, monkeys, rabbit and ferret, and summed up the characteristics and applicable range of each method. The making methods of constipation model were various, but that methods and observation index of constipation models were not in - depth. Detection technology of modern biochemical, molecular and cellular should be used for exploring constipation mechanism. The design thoughts of the models should conform to clinical constipation pathogenesis, and then the evaluation standards of specific constipation model should be found, that can provide convenience for the innovative research of constipation models and research and development of treating constipation medicines.

关 键 词：便秘 动物模型 药理学 

分 类 号：R285[医药卫生—中药学]