特康唑阴道栓治疗外阴阴道假丝酵母菌病多中心临床研究  

The efficacy and safety of terconazole suppositories for treatment of vulvovaginal candidiasis

作　　者：汪清[1] 郑瑞莲[1] 曹斌融[1] 狄文[2] 张惠英[2] 段涛[3] 黄冰清[3] 王玲[3] 戴晓星[3] 胡烈薇[4] 滕宗荣[4] 王敏敏[4] 

机构地区：[1]复旦大学附属妇产科医院,上海200011 [2]上海交通大学医学院附属仁济医院妇产科,上海200127 [3]上海市第一妇婴保健院,上海200040 [4]上海交通大学附属瑞金医院妇产科,上海200025

出　　处：《中国实用妇科与产科杂志》2012年第11期851-853,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的评价特康唑阴道栓治疗外阴阴道假丝酵母菌病(vulvovaginal candidiasis,VVC)的有效性和安全性。方法采用多中心、随机、双盲对照的研究方法,将2004年5月至8月在复旦大学附属妇产科医院等4家医院就诊并确诊的139例外阴阴道假丝酵母菌病患者随机分为治疗组(特康唑组70例)和对照组(硝酸咪康唑组69例)。连续用药7d,分别于给药后1周和4周进行临床疗效、微生物疗效和复发率比较。结果两组VVC患者治疗后症状和体征均得到有效控制,但治疗组在给药4周后的临床症状和微生物学检查的复发率均为0,对照组的复发率分别为10.17%、16.67%,差异有统计学意义(P<0.05)。两组的不良反应发生率分别为5.7%和5.8%,差异无统计学意义(P>0.05),均未见严重不良事件。结论特康唑阴道栓抗真菌谱广、复发率低、安全性好,可作为治疗VVC的一个新选择。Objective To evaluate the efficacy and safety of terconazole suppositories for treatment of Vulvovaginal Candidiasis.Methods 139 valid case were randomly assigned into observation group or control group for 7-day treatment in this randomized multi-center double blind study.During the trial,the follow-up visits were conducted at 1 and 4 weeks after treatment respectively.Clinic cure rates,microbiologic cure rates and relapse rates were observed in each follow-up visit.Results Both groups had significantly therapeutic cure rates.Clinic and microbiologic relapse rates for terconazole regimens,however,were 0 and control group were 10.17% and 16.67%,respectively.Conclusion Terconazole suppositories is a preferable candidate for treatment of Vulvovaginal Candidiasis.

关 键 词：特康唑阴道栓 外阴阴道假丝酵母菌病 疗效与安全性 

分 类 号：R711.3[医药卫生—妇产科学]