绿原酸大鼠口服吸收绝对生物利用度研究  

Study on oral absolute bioavailability of chlorogenic acid in rats

作　　者：任静[1] 蒋学华[2] 邓盛齐[1] 陶静[1] 

机构地区：[1]中国医药集团总公司四川抗菌素工业研究所,成都610052 [2]四川大学华西药学院,成都610041

出　　处：《中国抗生素杂志》2012年第11期847-850,共4页Chinese Journal of Antibiotics

基　　金：国家自然科学基金资助项目(项目编号30070935;30271614)

摘　　要：目的评价绿原酸大鼠口服吸收的绝对生物利用度。方法以绿原酸大鼠静脉注射给药后药动学参数AUC为参照,三组大鼠按照200、400、600mg/kg给药剂量分别灌胃给药,计算相关参数,按公式Fpo(%)=AUCpo×Div/(AUCiv×Dpo)×100%计算绝对生物利用度。结果静脉注射给药后AUC0→t为198.01±42.36mg/L·min.灌胃200、400、600mg/kg三个剂量下的AUC0→t分别为339.39±16.03、1268.31±207.08和2530.35±442.57mg/L·min,绝对生物利用度分别为34.28%、64.06%和85.2%。结论绝对生物利用度的评价为绿原酸制剂开发提供了有益参考。Objective To evaluate the absolute bioavailability of chlorogenic acid by intragastric administration in rats. Methods Chlorogenic acid was administrated by oral at doses of 200, 400 and 600mg/kg. Pharmacokinetic parameters were then calculated. Based on the pharmacokinetic parameter AUC by intravenous injection, absolute bioavailability was calculated as follow, Fpo（%）=AUCp0 × Div / （AUCiv × Dp0） × 100%. Results A UCo0→t of intravenous injection was 198.0 1±42.36mg/L.min. After intragastric administration, A UC0→t of 200, 400 and 600mg/kg group was 339.39＋16.03, 1268.31±207.08 and （2530.35±442.57）mg/L.min, respectively. The absolute bioavailability of this three group was 34.28%, 64.06% and 85.2%, respectively. Conclusion The evaluation of the absolute bioavailability provides a useful reference for the development of preparation of Chlorogenic acid.

关 键 词：绿原酸 大鼠 口服吸收 绝对生物利用度 

分 类 号：R969.1[医药卫生—药理学]