上尿路梗阻合并非特异性感染分析及耐药性研究  

Distribution and drug resistance of nonspecific infections in patients with upper urinary tract obstruction

作　　者：胡卫锋[1] 陈琳[1] 李国灏[1] 彭松[1] 余家俊[1] 万志华[1] 

机构地区：[1]武汉市中心医院泌尿外科,湖北武汉430014

出　　处：《中华医院感染学杂志》2012年第21期4776-4778,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究上尿路梗阻发生泌尿系感染患者的病原菌分布及其耐药性,以预防与控制尿路感染,并对临床抗菌药物的应用提供依据。方法对2009年5月-2011年11月泌尿外科上尿路梗阻患者中发生泌尿系感染的病例进行研究,按规范采集相应的尿液标本进行病原学培养及药敏试验。结果共分离到113株病原菌,革兰阴性杆菌75株占66.37%,革兰阳性球菌33株占29.20%,真菌5株占4.43%;其中大肠埃希菌42株占37.17%,肠球菌属17例占15.04%,葡萄球菌属13例占11.50%;多药耐药菌常见,产超广谱β-内酰胺酶大肠埃希菌的检出率为47.62%。结论革兰阴性杆菌是上尿路梗阻合并感染的主要病原菌,但肠球菌属及葡萄球菌属也占较大比例;病原菌耐药性高,且部分呈多药耐药;需合理应用抗菌药物,减少耐药菌株比例。OBJECTIVE To analyze the distribution and antibiotic resistance of the pathogens causing urinary tract infections in the patients with urinary tract obstruction so as to prevent and control urinary tract infections and provide basis for clinical application of antibiotics.METHODS The patients with urinary tract infections among the patients with upper urinary tract obstruction who were treated in department of urology from May 2009 to Nov 2011 were studied,the pathological culture for the corresponding sampling urine specimens and the drug susceptibility testing were performed.RESULTS There were totally 113 strains of pathogens isolated,including 75（66.37%） strains of gram-negative bacilli,33（29.20%） strains of gram-positive cocci and 5（4.43%） strains of fungi;there were 42 strains of Escherichia coli（37.17%）,17 strains of Enterococcus（15.04%）,13 strains of Staphylococcus（11.50%）;multidrug-resistant bacteria were common,and the detection rate of ESBLs-producing E.coli was 47.62%.CONCLUSIONGram-negative bacilli are the main pathogens causing nonspecific infections with upper urinary tract obstruction,and Enterococcus and Staphylococcus take a large proportion;the drug resistance of the pathogens is high and some of them display multidrug-resistant;it is necessary to reasonably use antibiotics so as to reduce drug resistant strains.

关 键 词：上尿路梗阻 感染 耐药性 

分 类 号：R181.32[医药卫生—流行病学]