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作 者:蒙以良[1] 黄广优[1] 李晓华[2] 黄月娟[1] 邓柑雀[1] 黄升武[1] 陈坚贤[1] 郑学嵩[1] 许群英[1] 李书有[1]
机构地区:[1]百色市人民医院肿瘤科,广西百色533000 [2]右江民族医学院微免教研室,广西百色533000
出 处:《中华医院感染学杂志》2012年第21期4803-4805,共3页Chinese Journal of Nosocomiology
摘 要:目的评价三维适形放疗同步化疗方案治疗原发性肝癌的临床疗效。方法将61例原发性肝癌患者随机分为治疗组和对照组,治疗组31例,给予三维适形放疗同步FOLFOX4(奥沙利铂+亚叶酸钙+5氟脲嘧啶)方案化疗,对照组30例,给予FOLFOX4方案化疗,观察两组患者的近期疗效、血清甲胎蛋白(AFP)变化、生存时间及不良反应。结果治疗组和对照组的治疗有效率分别为83.8%和60.0%,两组比较差异有统计学意义(P<0.05);治疗组AFP≥400μg/L的患者中由84.0%降至400μg/L,对照组AFP≥400μg/L的患者由59.1%降至<400μg/L,两组比较差异有统计学意义(P<0.05);治疗组的1~3年生存率分别为75.9%、58.6%和31.0%,对照组分别为60.7%、39.3%和17.9%,两组比较差异有统计学意义(P<0.01);两组的不良反应主要表现为胃肠道反应、骨髓抑制、肝功能损伤和手足综合征,两组比较差异无统计学意义。结论三维适形放疗同步FOLFOX4方案治疗原发性肝癌的能提高近期疗效、降低AFP,延长生存时间。OBJECTIVE To evaluate clinical efficacy of three-dimensional conformal radiotherapy concurrent with FOLFOX4 program for primary hepatocellular carcinoma.METHODS A total of 61 patients with primary hepatocellular carcinoma were randomly divided into the treatment group and the control group,in treatment group,31 patients received three-dimensional conformal radiotherapy combined with FOLFOX4 regimen(Oxaliplatin+CF+5-FU),30 patients only received chemotherapy with FOLFOX4 regimen in the control group.The short-term effect,changes of AFP,survival time and side effects were observed in two groups.RESULTS The effective rate of the treatment in the treatment group was 83.8%,significantly higher than 60.0% in control group,the difference was statistically significant(P0.05);there were 84.0% of the patients in the treatment group AFP down to 400μg/L,and there were 59.1% of the patients in the control group with AFP more than 400μg/L decreasing to less than 400μg/L,the difference was statistically significant(P=0.01);in the treatment group,the survival rates of the first,second,and third year were 75.9%,58.6%,and 31.0%,significantly higher than 60.7%,39.3% and 17.9% in the control group,the difference was statistically significant(P0.01).The adverse reactions of the two groups were mainly the gastrointestinal side effects,bone marrow suppression,liver dysfunction,and hand-foot syndrome,the differences were not statistically significant.CONCLUSION Three-dimensional conformal radiotherapy combined with FOLFOX4 regimen for primary hepatocellular carcinoma can improve the short-term effect,reduce the level of AFP,and prolong survival time.
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