产超广谱β-内酰胺酶大肠埃希菌的分布及耐药性分析  

Clinical distribution and drug resistance of ESBLs-producing Escherichia coli

作　　者：许向锋[1] 翟瑞山[1] 

机构地区：[1]泰山医学院附属莱钢医院检验科,山东莱芜271126

出　　处：《中华医院感染学杂志》2012年第21期4887-4888,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解医院产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的发生率和耐药性,为临床合理选择抗菌药物提供依据。方法采用纸片扩散法(K-B)检测2009年5月-2011年5月门诊及住院患者送检标本检出的细菌对抗菌药物敏感性;用双纸片扩散确诊试验检测产ESBLs。结果在174株大肠埃希菌中共检出产ESBLs大肠埃希菌112株,检出率为64.4%;产ESBLs大肠埃希菌对临床常用抗菌药物具有多药耐药性,对头孢唑林、头孢曲松、头孢噻肟均100.0%耐药,对氨曲南、氨苄西林、哌拉西林、环丙沙星、庆大霉素的耐药率分别为99.1%、99.1%、98.2%、88.4%、69.6%。结论应加强产ESBLs大肠埃希菌监测,合理使用抗菌药物,防止产ESBLs大肠埃希菌医院感染的暴发流行。OBJECTIVE To study drug resistance of ESBLs-producing Escherichia coli,to provide basis for rational application of antibiotics.METHODS The antibiotic susceptibility testing was performed by Kirby-Bauer method.ESBLs-producing isolates were confirmed by double disk diffusion confirming test.RESULTS Among 174 E.coli isolates,there were 112（64.4%）ESBLs-producing strains;ESBLs-producing E.coli was multidrug-resistant to commonly used antibiotics,and the drug resistance rates to cefazolin,ceftriaxone and cefotaxime were 100.0%,the resistance rates to aztreonam,ampicillin,piperacillin,ciprofloxacin,and gentamicin of ESBLs-producing E.coli were 99.1%,99.1%,98.2%,88.4% and 69.6%,respectively.CONCLUSION It is necessary to strengthen the surveillance of ESBLs-producing E.coli and reasonably use of antibiotics so as to prevent the outbreak and spread of ESBLs-producing E.coli infections.

关 键 词：产超广谱Β-内酰胺酶 大肠埃希菌 临床分布 耐药性 

分 类 号：R378[医药卫生—病原生物学]