165株鲍曼不动杆菌的分布及耐药性分析  

Analysis on Distribution and Drug Resistance of 165 Strains of Acinetobacter Baumannii

作　　者：徐晓松[1] 李瑞莹[1] 陈林珍[1] 陈少莲[1] 

机构地区：[1]广东药学院附属第一医院,广东广州510080

出　　处：《临床医学工程》2012年第11期2048-2049,共2页Clinical Medicine & Engineering

摘　　要：目的分析了解广东药学院附属第一医院2011年6月至2012年6月临床标本分离培养鲍曼不动杆菌的分布及耐药性特点。方法 165株鲍曼不动杆菌的分布及耐药性进行分析,药敏试验采用MIC法及K-B法。判断标准参考CLSI2010年版标准。结果对所研究的这165株菌中,绝大部分(87.9%)是从痰标本中分离得到,ICU病区分布占了主要部分(26.1%)。临床常用治疗药物中,鲍曼不动杆菌对多黏菌素E及头孢哌酮/舒巴坦的敏感性较好(>75%),其它临床常用药物的敏感性均较差(<50%)。结论由于抗生素的广泛应用,且未能得到很好的规范化使用,鲍曼不动杆菌已成为医院感染的重要病原菌之一,且对常用抗生素耐药情况严重,更为甚者达到全耐。所以应加强对临床使用抗生素的监测及控制,减少及防止鲍曼不动杆菌引起的院内感染的发生。Objective To understand and analyze the distribution and the resistance ofAcinetobacter baumannii in clinical specimens from the First Affiliated Hospital of Guangdong Pharmaceutical University bewteen June 2011 and June 2012. Methods The distribution and the resistance of 165 strains of Acinetobacter baumannii were analyzed. The anticrobial susceptibility testing （AST） was determined by minimal inhibitory concentration （MIC） test and K-B disk diffusion method. The AST was performed as recommended by CLISI 2010. Results Most of the 165 strains of A cinetobacter baumannii （87.9%） were examined from phlegm, and most of these strains （26.1%） were from ICU. Those commonly used antibiotics for the clinical therapy, the Polymyxin E and the Cefoperazone/sulbactam were more sensitive for the A cinetobacter baumannii （〉75%）, while other commonly used antibiotics were less sensitive （〈50%）. Conclusions Due to extensive use of antibiotics, and without well standardized use, A cinetobacter baumannii has become one of the important pathogens of nosocomial infection, and serious resistance to commonly used antibiotics, furthermore, some of these stains have drug resistance to all of the commonly used antibiotics. Therefore, monitoring and control of clinical use of antibiotics should be strengthened to reduce and prevent the occurrence of nosocomial infections caused by A c ine tob ac te r b aumannii.

关 键 词：鲍曼不动杆菌 耐药性 分析 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]