肺泡蛋白沉积症21例临床分析  

Clinical analysis of pulmonary alveolus proteinosis in 21 cases

作　　者：王伟[1] 张映铭[1] 王彩英[1] 刘晓甦[2] 黄怡真[2] 万明月[3] 

机构地区：[1]南京胸科医院呼吸内科,肺灌洗中心,南京210029 [2]南京胸科医院麻醉科,南京210029 [3]南京胸科医院病理科,南京210029

出　　处：《临床肺科杂志》2012年第12期2168-2170,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨肺泡蛋白沉积症的临床特征和诊疗方法方法分析1996年～2011年住院的21例肺泡蛋白沉积症患者的临床资料。结果肺泡蛋白沉积症常见症状为渐进性呼吸困难伴咳嗽咳痰,典型胸部CT表现为两肺浸润影,伴地图征和铺路石征,确诊依靠肺活检病理和肺泡灌洗液PAS染色,全肺大容量灌洗仍为目前确切有效缓解病情的治疗方法。结论肺泡蛋白沉积症临床表现无特异性,临床医生宜熟悉该病的临床特点和影像学表现,及时明确病理诊断并予全肺灌洗术治疗。Objective To explore the clinical features, diagnosis and therapy of pulmonary alveolus proteinosis. Methods The data of 21 patients with pulmonary alveolus proteinosis from 1996 to 2011 were reviewed. Results The common clinical symptom was gradual dyspnea and cough and expectoration, and the typical CT appearance was pulmonary infiltration. The way to make a definite diag- nosis was lung biopsy and bronchoalveolar lavage fluid PAS dyeing. The whole lung lavage was still the most efficient and safety therapy. Conclusion As a rare but potentially threatening respiratory disease, the clinical feature of PAP is untypical, but the doctor should know its clinical features and imageology well so as to take the whole lung lavage and other related treatments timely.

关 键 词：肺泡蛋白沉积症 全肺灌洗 

分 类 号：R563.9[医药卫生—呼吸系统]