纳洛酮联合NIPPV治疗AECOPD合并肺性脑病的临床观察  

Clinical observation of naloxone treatment combined with noninvasive positive pressure ventilation on chronic obstructive pulmonary disease with pulmonary encephalopathy

作　　者：童亚玲 李乾兵[1] 徐建林[1] 

机构地区：[1]安庆市第一人民医院呼吸内科,安徽安庆246003

出　　处：《临床肺科杂志》2012年第12期2179-2181,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨纳洛酮联合无创正压通气(NIPPV)呼吸机治疗AECOPD合并肺性脑病的疗效。方法 66例AECOPD合并肺性脑病的患者随机分为3组:对照组、NIPPV组、NIPPV联合纳洛酮组。观察3组动脉血气、插管率、住院时间及住院费用、死亡率。结果 NIPPV加纳洛酮组与对照组及NIPPV组相比,治疗后PaCO2、插管率、住院时间、住院费用、死亡率均明显下降,PaO2、pH值明显改善,差异均具有统计学意义(P<0.05)。结论早期使用纳洛酮联合NIPPV治疗AECOPD合并肺性脑病患者,能明显改善症状,减少气管插管,迅速纠正低氧血症和CO2潴留,缩短住院时间,降低住院费,降低死亡率。Objective To investigate the efficacy of naloxone combined with non-invasive positive pressure ventilation （NIPPV） in the treatment of acute exacerbations of chronic obstructive pulmonary disease （AECOPD） with pulmonary encephalopathy. Methods 66 AECOPD patients with pulmonary encephalopathy were randomly divided into three groups ： the control group, the NIPPV group and the naloxone combined with NIPPV group. Their arterial blood gas, intubation rate, hospital stays and expenses, and mortality were observed and recorded. Results PaCO2 , intubation rate, hospital stays and expenses, and mortality in the NIPPV combined with naloxone group were significantly decreased, and the differences had statistical significance （ P 〈 0.05 ）. Conclusion Early use of naloxone combined with NIPPV in the treatment of AECOPD patients with pulmonary encephalopathy can significantly reduce the endotracheal intubation, cor- rect hypoxemia and CO2 retention rapidly, cut hospital stays and expenses, and reduce mortality.

关 键 词：慢性阻塞性肺疾病 肺性脑病 纳洛酮 无创辅助通气 

分 类 号：R563.9[医药卫生—呼吸系统]