早期CRRT干预抢救重度有机磷农药中毒治疗体会  

Treatment experience of early CRRT intervention on severe organophosphorus pesticide intoxication

作　　者：曹磊[1] 江莲[1] 侯昕珩[1] 谢诤[1] 谢伟国[1] 

机构地区：[1]东南大学附属江阴人民医院呼吸科,江苏江阴214400

出　　处：《临床肺科杂志》2012年第12期2186-2187,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究早期CRRT干预抢救重度有机磷农药中毒的疗效。方法 70例患者分为甲乙两组,其中甲组予CRRT,乙组给予常规阿托品+解磷定治疗,观察两组动脉血气变化、胆碱酯酶恢复正常所需时间、阿托品用量、MODS发生率、治愈率。结果与乙组相比,甲组治愈率明显提高,MODS发生率减少、胆碱酯酶恢复正常所需时间明显缩短、阿托品用量明显减少(P<0.01);结论在目前常规治疗的基础上,采用早期联合CRRT抢救急性重度有机磷农药中毒成功率更高,值得推广。Objective To study the early CRRT intervention on severe organophosphorus pesticide intoxication. Methods 70 patients were randomly divided into two groups, who were all given conventional atropine and pralidoxime treatment. For the group A, they were given atropine and pralidoxime treatment plus CRRT, and the group B were treated with atropine and pralidoxime only. Those who had respiratory failure were given ventilator additionally. The following items were observed and recorded ： arterial blood gas changes, the time of cholinesterase back to normal, the dosage of atropine, and the incidence and cure rate of MODS. Results Compared with the group B, the cure rate of the group A was obviously higher, and the time of cholinesterase back to normal and the dosage of atropine decreased manifestly （ P 〈 0.01 ）. Conclusion At present, it can improve the cure rate of acute severe organophosphorus pesticide intoxi- cation on the basis of conventional therapy combined with CRRT, and it＇s worth to be applied in clinical practice.

关 键 词：CRRT 重度有机磷农药重度 治疗体会 

分 类 号：R595.4[医药卫生—内科学]