血清脂蛋白(a)与妊娠高血压综合征发病的关系  

Serum Lipoprotein(a)in Woman with Pregnancy Induced Hypertension

作　　者：赵滢[1] 唐慧君[1] 吕世杰[2] 汤洁心 马悦[1] 吴白涛[1] 

机构地区：[1]大连医科大学第二临床学院妇产科,116023 [2]大连市妇产医院

出　　处：《中华妇产科杂志》2000年第3期145-147,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　检测妊娠高血压综合征 (妊高征 )患者血清中脂蛋白 (a)的水平 ,以探讨脂蛋白(a)在妊高征发病中所起的作用。方法　应用透射比浊法检测 32例妊高征患者 (妊高征组 )及 2 0例正常妊娠妇女 (对照组 )血清中脂蛋白 (a)水平 ,应用酶法及间接沉淀法测两组孕妇血清中胆固醇(TC) ,甘油三酯 (TG) ,高密度脂蛋白胆固醇 (HDL C)的水平 ,应用Friedewald公式计算出低密度脂蛋白胆固醇 (LDL C)水平。结果　 (1)妊高征组血清中脂蛋白 (a)的水平 [(2 2 8± 187)mg/L]高于对照组[(10 6± 93)mg/L],两组比较 ,差异有非常显著性 (P <0 .0 0 2 )。 (2 )妊高征组轻、中、重度患者脂蛋白(a)的水平显示 :轻度患者 [(10 9± 84)mg/L]略高于对照组 ;中度患者 [(2 5 8± 2 30 )mg/L]及重度患者[(2 76± 16 6 )mg/L]显著高于对照组。 (3)妊高征组血清中TC ,TG ,LDL C的水平分别为 (6 .17± 1.2 8)mmol/L ,(3.3± 0 .81)mmol/L和 (3.71± 1.32 )mmol/L ;对照组分别为 (5 .42± 0 .81)mmol/L ,(2 .78±0 .88)mmol/L和 (3.0 6± 1.32 )mmol/L。两组比较 ,差异均有显著性 (P <0 .0 5 )。妊高征组HDL C的水平为 (0 .98± 0 .16 )mmol/L ,低于对照组的 (1.0 9± 0 .17)mmol/L。两组比较 ,差异有显著性 (P <0 .0 5 )。Objective To examine lipoprotein(a) level in woman with Pregnancy induced hypertension (PIH) to elucidate the effect of it on the pathogenesis of the disease. Methods Serum lipoprotein (a) total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL C) and low density lipoprotein cholesterol (LDL C) levels were measured in 20 normal pregnant woman (control group) and 32 pregnant woman with PIH (PIH group). The PIH group was further divided into the following subgroup: mild, moderate, and severe PIH. We used a transmission turbidimetry method to measure serum lipoprotein(a). Results (1) The serum lipoprotein (a)levels were higher in PIH group than that in control group (228±187 mg/L vs 106±93 mg/L). (2) The serum lipoprotein (a) levels were higher in all PIH subgroups than that in control. (3) The serum levels of TC, TG, LDL C in the PIH group were higher than those in control, while the level of HDL C in the PIH group was lower than that in control (0.98±0.16 mmol/L vs 1.09±0.17 mmol/L). Conclusions This study has demonstrated that lipoprotein (a) levels are elevated in pregnant woman with PIH and associated with severity of the disease. It may involved in the pathogenesis of PIH.

关 键 词：妊娠并发症 心血管 高血压 脂蛋白(a) 

分 类 号：R714.246[医药卫生—妇产科学]