紫草素及其衍生物的生物合成与药理研究进展  

Recent advances in the study of pharmacology and biosynthesis of shikonin and its derivatives

作　　者：刘根林[1,2] 王小明[1] 杨永华[1] 

机构地区：[1]江苏省林业科学研究院,江苏南京211153 [2]南京大学生命科学院医药生物技术国家重点实验室,江苏南京210093

出　　处：《江苏林业科技》2012年第5期45-50,共6页Journal of Jiangsu Forestry Science & Technology

基　　金：国家自然科学基金资助项目(30711041);中国博士后基金资助项目(20060400917);江苏省博士后基金资助项目(No.060200213)

摘　　要：天然紫草素类化合物具有消炎、抗菌、抗病毒和抗肿瘤等功效。由于活性广谱,近年来对其研究众多,涌现出大量的研究成果。该文就紫草素及其衍生物活性和生物合成方面近十几年的研究进行归纳和总结,并着重对天然紫草素类化合物与紫草素类合成衍生物的抗肿瘤活性进行比较,从而为紫草素及其衍生物活性的进一步研究提供可能的依据。Natural shikonin-like compounds possess anti-inflammatory,anti-bacterial,anti-viral and anti-tumor activities.With these wide-ranged effects,a huge quantity of researches has recently centered on them.In this paper,the past over decade＇s study of their and their analogues＇ activities and biosynthesis is reviewed.And a comparison between anti-tumor activities of natural shikonin-like compounds and those of synthetic derivatives has been made.A possible guidance for the further relative study has been provided as well.

关 键 词：紫草素 紫草素衍生物 药理 生物合成 

分 类 号：S567.9[农业科学—中草药栽培]