子宫内膜异位症患者血清与腹腔液中肿瘤坏死因子α及白细胞介素6的测定  

Evaluation of Tumor Necrosis Factor alpha and Interleukin-6 Levels in Serum and Peritoneal Fluid of Patients with Endometriosis

作　　者：李斌[1] 金福明[1] 杨来春[2] 朱关珍[1] 

机构地区：[1]上海医科大学妇产科医院妇科,200011 [2]上海医科大学附属中山医院妇产科

出　　处：《中华妇产科杂志》2000年第3期166-168,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　了解子宫内膜异位症 (内异症 )患者血清及腹腔液中肿瘤坏死因子α(TNF α)、白细胞介素 6 (IL 6 )的水平以及在腹腔镜保守性手术治疗后的变化。方法　收集内异症Ⅰ、Ⅱ期及Ⅲ、Ⅳ期患者各 10例 (共 2 0例 )的腹腔镜手术前后的血清和腹腔液 ,并以经腹腔镜检查确诊为与内异症无关病例 10例为对照 ,应用放射免疫双抗体夹心法与放射免疫固相包被法分别测定其TNF α及IL 6水平。结果　内异症患者血清和腹腔液TNF α、IL 6水平 ,均与疾病分期呈正相关 (r值分别为 :血清 :0 .80 ,0 .5 2 ;腹腔液 :0 .79,0 .49;P均 <0 .0 5 ) ,且随腹腔镜保守性手术后内异灶的清除而有明显下降。结论　血清和腹腔液TNF α、IL 6水平对术后随访、监测及手术效果的评价有重要价值。Objectives To evaluate the levels of tumor necrosis factor alpha (TNF α)and interleukin 6 (IL 6) before and after conservative laparoscopic surgery in patients with endometriosis. Methods The TNF α and IL 6 levels in serum and peritoneal fluid of 20 endometriotic patients and 10 control patients were determined by radioimmunoassay. Results Significant parallel relationship existed between the stage of endometriosis and the TNF α and IL 6 levels in serum and peritoneal fluid in endometriosis patients ( r values: serum: 0.80,0.52; peritoneal fluid: 0.79,0.49, P <0.05). After clearance of endometriosis foci with laparoscopic conservative surgery, the TNF α and IL 6 levels decreased significantly. Conclusion Measuring TNF α and IL 6 level may have important value in postoperative follow up, surveillance and evaluation of the effectiveness of surgery.

关 键 词：子宫内膜异位症 细胞活素类 肿瘤坏死因子 白细胞介素6 腹腔镜手术 

分 类 号：R711.71[医药卫生—妇产科学]