腹膜重建门静脉后腔面6-酮-前列腺素F_(1α)及一氧化氮合酶的变化  

The change of 6-k-PGF_(1α) and NOS on the luminal surface of the autoperitoneal tube grafts implanted into the portal vein

作　　者：陈伟强[1] 区庆嘉[1] 赵善广[1] 吴一冲[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院肝胆外科,广州510120

出　　处：《中华实验外科杂志》2000年第2期158-160,共3页Chinese Journal of Experimental Surgery

基　　金：广东省科委 97重点攻关项目 ![1997( 77) 0 2 5 ] ;广东省卫生厅 1998年医学科研项目! (B19980 2 8)

摘　　要：目的　了解腹膜重建门静脉后腔面 6 酮 前列腺素F1α(6 k PGF1α)、一氧化氮合酶(NOS)的变化及重建门静脉后的通畅率。方法　采用健康幼猪 2 5头 ,切除 1段门静脉 ,分别代以自体腹膜和自体静脉 ,观察移植后不同时期通畅率、组织病理变化并测定移植物腔面 6 k PGF1α、NOS含量。结果　腹膜重建门静脉后 1个月、2～ 3个月及 5个月时通畅率分别为 94.1%、76 .9%及71.4% ,与对照组比较差异无显著性 (P >0 .0 5 )。腹膜间皮细胞可释放 6 k PGF1α,并具有NOS ,2组移植前后腔面 6 k PGF1α比较差异无显著性 (P >0 .0 5 ) ,NOS移植后期已恢复接近正常。结论　腹膜重建门静脉有较高的通畅率 ,间皮细胞可释放 6 k PGF1α,并具有NOS ,其释放量和酶活性与移植血管创伤修复有关。Objective To study whether the peritoneum could produce 6 k PGF 1α ,NOS and its alternation after portal vein reconstruction. Methods Twenty five small healthy pigs were used in the study. A segment of portal vein was resected and reconstructed by autogenous peritoneum and vein respectively. The patency, pathological changes of the grafts, alternation of 6 k PGF 1α and NOS on the luminal surface of the grafts were investigated. Results One month,2-3 months and 5 months after portal vein reconstruction with peritoneum, the patency rate was 94.1%,76.9% and 71.4% respectively,showing no obviously different from the control group.The mesotheliun could produce 6 k PGF 1α and NOS. There was no significant difference between two groups in 6 k PGF 1α releasing. The NOS was approximately normal in the late stage of transplantation. Conclusion Postal vein reconstruction using autogenous peritoneum revealed a high patency. The peritoneum could produce 6 k PGF 1α and NOS. The releasing amount and activity of enzyme are related to the trauma and repairing.

关 键 词：门静脉重建 6-K-PGF1Α 自体腹膜 猪 

分 类 号：R602[医药卫生—外科学]