冠状动脉内注射硝普钠对冠状动脉慢血流的影响  

Effect of Intracoronary Nitroprusside Injection on Coronary Slow Flow

作　　者：张守信[1] 常快乐[2] 汤洪 赵智凝[1] 

机构地区：[1]解放军第451医院,陕西西安710054 [2]解放军第三医院,陕西宝鸡721004

出　　处：《现代生物医学进展》2012年第29期5692-5694,5729,共4页Progress in Modern Biomedicine

摘　　要：目的:观察冠状动脉内注射硝普钠对冠状动脉慢血流(CSF)的影响,为临床治疗CSF提供新方法。方法:将2010年1月至2010年12月,在我院心脏内科住院,伴有胸痛症状,经冠脉造影(CAG)诊断为CSF的患者12例,经患者知情同意后,通过冠状动脉造影导管向冠状动脉内注射硝普钠200～400μg后,3～5分钟内观察冠状动脉血流速度的改善情况,对比冠状动脉内注射硝普钠前后冠状动脉血流帧计数,根据CTFC帧计数,评估冠状动脉内注射硝普钠对冠状动脉血流速度的影响。结果:冠状动脉内注射硝普钠200～400μg后患者冠脉血流速度明显改善,冠状动脉血流帧计数较治疗前明显降低,差异有统计学意义(P<0.05),治疗改善率达83.3%,且患者治疗过程中无低血压等不良反应发生。结论:冠状动脉注射硝普钠可安全、有效地改善CSF患者冠状动脉慢血流现象。ABSTRACT Objective： To observe the effect of intracoronary nitroprusside injection on coronary slow flow （CSF）. Methods： 12 patients with CSF accompanied with chest pain from 2010 to 2010 were selected and treated with intracoronary injection of 200-400μg nitroprusside. CTFC of CAG were observed before and after the treatment within 3-5 minutes to assess blood flow velocity of coronary artery. Results： The CTFC was significantly lower in treatment with intracoronary injection ofnitroprusside. There was significant difference before and after treatment （29.6±5.51 vs 21.5± 4.37 P〈0.05, respectively）. The improvement rate was 83.3%, and no adverse effect such as hypotension was observed during the treatment. Conclusion： Intracoronary Nitroprusside injection was capable to effectively and securely improve coronary artery blood flow velocity. Key words： Nitroprusside; Coronary slow flow; Intracoronary injection

关 键 词：硝普钠 冠状动脉慢血流 冠状动脉内注射 

分 类 号：R541.9[医药卫生—心血管疾病]