在不孕症治疗中运用羧甲基壳聚糖液通液并留置的疗效分析  

Analysis on Effect of Using and Retaining Carboxy Methylchitosan Liquid in Infertility Treatment

作　　者：张珺[1] 徐辉[1] 张淑香[1] 冯益敏 秦灵慧[1] 

机构地区：[1]淮安市第二人民医院,江苏淮安223002

出　　处：《现代生物医学进展》2012年第30期5882-5885,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨在宫腹腔镜联合治疗不孕症术中、术后,使用羧甲基壳聚糖液通液及其宫腹腔留置对降低输卵管再次粘连及术后半年内宫内妊娠率的疗效。方法:将宫腔无异常,且双侧输卵管远端完全端梗阻的108例患者随机分为两组。宫腹腔镜术中及术后3月用羧甲基壳聚糖液+地塞米松通液并宫、腹腔留置羧甲基壳聚糖液组为实验组,用糜蛋白酶+庆大霉素+生理盐水+地塞米松通液组为对照组。分别记录两组术中及术后3月后输卵管通畅率及半年内宫内妊娠率的结果。结果:术中及术后3月实验组输卵管通畅率分别为90.0%、88.9%;对照组输卵管通畅率分别为88.7%、74.5%。半年内宫内妊娠率实验组为49.1%;对照组为28.3%。两组术中输卵管通畅率比较无显著差异(P>0.05)。术后3月输卵管通畅率比较差异有统计学意义(P<0.05),宫内妊娠率比较差异有统计学意义(P<0.05)。结论:使用羧甲基壳聚糖液通液及其宫腹腔留置可以降低术后输卵管再次粘连及提高宫内妊娠率。Objective： To investigate the combination therapy in laparoscopic surgery after infertility by using of carboxymethyl chitosan liquid and the liquid palace to reduce abdominal lien tubal adhesion and again after half a year within the curative effect of household pregnancy rates. Methods： The 108 cases of normal uterine cavity, and bilateral distal tubal completely end obstruction were randomly divided into two groups. The experimental group used the carboxymethyl chitosan solution ＋ dexamethasone and abdominal indwelling carboxymethyl chitosan in laparoscopy surgery and 3 months later,the control group used chymotrypsin ＋ gentamicin ＋ saline ＋ dexamethasone. Record the tubal patency rate of the two groups in intraoperative and 3 months later, and record the results of the intrauterine pregnancy rate within six months. Results： The tubal patency rate of the experimental group in intraoperative and 3 months later was respectively 90.0 % and 88.9 %; while that of the control group was 88.7 % and 74.5 %; Within six months, intrauterine pregnancy rate of the experimental group was 49.1% intrauterine pregnancy rate of the control group was 28.3 %. The tubal patency rate in the two groups of patients showed no significant difference （P〉 0.05）; the difference of the tubal patency rate showed statistically significant after 3 months later （P 〈0.05）; the difference of intrauterine pregnancy rate also showed statistically significant （P 〈0.05）. Conclusion： Use of carboxymethyl chitosan liquid and the liquid palace can reduce abdominal lien postoperative tubal adhesion and improve again intrauterine pregnancy rate.

关 键 词：羧甲基壳聚糖液 通液 宫腹腔留置 防粘连 

分 类 号：R713[医药卫生—妇产科学]