聚-(3-羟丙基)-DL-天冬酰胺组织相容性的初步观察  

Evaluation for Biocompatibility of Poly (3 hydroxypropyl) DL Aspartamide

作　　者：翁立红[1] 汤谷平[2] 周俊[1] 王斌[2] 周涛[3] 陈启琪[2] 

机构地区：[1]浙江大学医学院组胚教研室,杭州310006 [2]浙江大学药学院,杭州310006 [3]宁波大学食工系,宁波315211

出　　处：《生物医学工程学杂志》2000年第1期19-20,28,共3页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目!(39570219)

摘　　要：药物控释高分子材料要求有良好的生物相容性。我们对聚 - (3-羟丙基 ) - DL-天冬酶胺 (PHPA)材料进行了皮下埋植实验、组织病理学观察、血生化和微核等检测。早期 ,在埋植部位出现了异物反应 ,第 13天部分小鼠肝组织小血管边出现轻度炎症反应 ,34 d后上述反应逐渐减轻或消失 ,肝肾组织细胞形态和功能基本正常。实验表明 。To evaluate the biocompatibility of poly (3 hydroxypropyl) DL aspartamide(PHPA), we utilized the laboratory methods, including subcutaneous implantation, histological examination, blood biochemical and micronucleus test. Histological examination revealed a nonspecific foreign body reaction around the PHPA and a slight inflammation around the small blood vessels of the liver on the 13th day, but all these reactions diminished or disappeared gradually after 34 days of implantation. The structures and functions of liver and kidney were normal. The results indicate that PHPA possesses a good nature in biocompatibility.

关 键 词：PHPA 生物相容性 皮下埋植 聚天冬酰胺 

分 类 号：R318.08[医药卫生—生物医学工程]