复方雷公藤外敷降低类风湿关节炎疾病活动度的研究  

External Application of Compound Tripterygium wilfordii Decreased the Activity of Rheumatoid Arthritis

作　　者：焦娟[1] 姜泉[1] 

机构地区：[1]中国中医科学院广安门医院风湿病科,北京100053

出　　处：《中国中西医结合杂志》2012年第11期1470-1472,1476,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市科技计划首都临床特色应用研究(No.Z111107058811104)

摘　　要：目的探索在中西医结合治疗基础上,复方雷公藤外敷类风湿关节炎(RA)的疗效。方法将67例湿热瘀阻证活动期RA患者随机分为外敷组35例和安慰剂组32例,以美国风湿病协会(ACR)反应标准和疾病活动性评分(disease activity score,DAS)为疗效评价指标,进行为期4周,随访3个月的随机对照单盲临床研究,采用意向性分析集进行统计分析。结果治疗后外敷组和安慰剂组ACR20达标率分别为34.3%、12.5%,DAS28评分下降的均值分别为1.07、0.40,两组比较差异均有统计学意义(P<0.05,P<0.01)。安全性方面,外敷组未见对月经有影响,仅见2例轻度皮肤过敏,停药后可缓解。结论复方雷公藤外敷可控制类风湿关节炎病情、降低疾病活动度,且安全性较好。Objective To explore the therapeutic efficacy of external application of Compound Tripterygium wilfordii （CTW） for treating rheumatoid arthritis （RA） on the basis of treatment by integrative medicine. Methods Totally 67 active RA patients of damp-heat stagnation syndrome were randomly assigned to the external application group （35 cases） and the placebo group （32 cases）. The reaction standard by American College of Rheumatology and Disease Activity Score （DAS） were taken as the indices for therapeutic assessment. A randomized controlled, single blind clinical trial was performed for 4 weeks, with a 3-month follow-up. The statistical analyses were performed using intention to treat analysis set （ITT）. Results After treatment the rate of reaching ACR20 was 34.3% and 12.5% in the external application group and the placebo group respectively. The mean for the average drop of DAS28 ratings was 1.07 in the external application group and 0.40 in the placebo group, showing statistical difference （P0.05, P0.01）. As for the safety, there was no effect on the menstruation in the external application group. Only mild skin allergy occurred in 2 cases of the external application group, but they were alleviated after drug withdrawal. Conclusions External application of CTW could control the condition of RA and reduce the disease activity of RA. It had better safety.

关 键 词：复方雷公藤 外敷法 类风湿关节炎 

分 类 号：R285.5[医药卫生—中药学]