速效救心丸对急性冠脉综合征患者早期经皮冠状动脉介入效果的影响  

Effects of Suxiao Jiuxin Pill on Patients with Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention

作　　者：王肖龙[1] 刘永明[1] 朱谷晶[1] 薛金贵[1] 戎靖枫[1] 陈铁军[1] 沈智杰[1] 郭蔚[1] 

机构地区：[1]上海中医药大学附属曙光医院心内科,上海201203

出　　处：《中国中西医结合杂志》2012年第11期1483-1487,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：上海市卫生局资助项目(No.20114049);上海市中医临床重点实验室资助项目(No.C10dz2220200)

摘　　要：目的探讨速效救心丸对急性冠脉综合征(acute coronary syndrome,ACS)患者早期经皮冠状动脉介入(percutaneous coronary intervention,PCI)效果的影响。方法 60例ACS患者随机分为速效救心丸加载治疗组30例(治疗组)和单用西药对照组30例(对照组),两组均行行冠状动脉造影检查,并行早期PCI,观察速效救心丸干预对ACS患者支架植入前后冠脉血流、血管侧支开放以及围手术期心肌梗死发生率的影响。结果无论PCI术前还是术后,治疗组的冠脉血流均优于对照组,术前心肌梗死溶栓(thrombolysis in myocardial infarction,TIMI)血流分级达到3级者:16/30vs11/30,P<0.01;术后TIMI血流达到3级者:14/14vs13/19,P<0.05;在TIMI血流0～1级的患者中,治疗组有侧支保护者明显较对照组多(5/6vs3/13,P<0.05);治疗组围术期心肌梗死的发生率明显低于对照组(8/30vs15/30,P<0.05)。结论速效救心丸有改善ACS患者支架植入前后的冠脉血流、增加侧支开放及减少围手术期心肌梗死的发生率的作用。Objective To investigate the intervention effects of Suxiao Jiuxin Pill （SJP） on patients with acute coronary syndrome （ACS） undergoing early percutaneous coronary intervention （PCI）. Methods Sixty ACS patients were randomly assigned to the treatment group （treated by SJP and Western medicine） and the control group （treated by Western medicine alone）, 30 in each group. Coronary arteriography and early PCI were performed in all patients. The effects of SJP on the blood flow rate, the collateral artery patency, and perioperative myocardial infarction incidence were observed. Results The coronary blood flow rate was better in the treatment group than in the control group either pre-or post-PCI. [pre-PCI thrombolysis in myocardial infarction （TIMI） level Ⅲ： 16/30 vs 11/30, P0.01; post-PCI TIMI level Ⅲ： 14/14 vs 13/19, P0.05）]. In patients with ITMI level 0-Ⅰ, more patients in the treatment group had collateral artery protective function than those in the control group （5/6 vs 3/13, P0.05）. The incidence of perioperative myocardial infarction was obviously lower in the treatment group than in the control group （8/30 vs 15/30, P0.05）. Conclusion SJP could improve the pre-and post-PCI coronary artery flow rate, increase the collateral artery patency, and reduce the incidence of perioperative myocardial infarction of ACS patients.

关 键 词：速效救心丸 急性冠脉综合征 冠状动脉造影 经皮冠状动脉介入 侧支循环 围手术期心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]