代谢综合征与前列腺体积的相关性研究  

Association between metabolic syndrome and prostate volume

作　　者：盛斌武[1] 马茂[1] 

机构地区：[1]西安交通大学医学院第一附属医院老年外科,710061

出　　处：《中华老年医学杂志》2012年第11期935-937,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨代谢综合征（MS）各相关指标与前列腺体积的相关性。方法采用随机数字法从健康查体的10056例中挑选30～49岁男性843例，测量患者血压、体质量、身高、腰围，并计算体质指数（BMI）。生化分析包括检测晨空腹血糖、总胆固醇、三酰甘油（TG）、高密度脂蛋白（HDL—c）、血前列腺特异抗原（PSA），并进行尿常规分析。采用直线回归分析评估MS及相关指标与前列腺体积的相关性。结果MS患者前列腺体积（28．3±5．5）ml明显大于对照组（23．2±5．6）ml（P％0．05），空腹血糖、收缩压、BMI、腰围异常组前列腺体积分别为（25．4±5．5）ml、（25．5±5．8）ml、（25．4±5．3）ml、（30．2±4．8）ml，亦大于对照组（23．6±5．5）ml、（23．4±5．4）ml、（22．6±5．5）ml、（23．5±5．3）ml（均P〈0．05）。前列腺体积与BMI、收缩压、腰围、空腹血糖、TG呈正相关（r=0．397、0．170、0．411、0．216、0．184，均P〈0．05），与HDL-C呈负相关（r=-0．107，P〈0．05）。结论MS各相关指标尤其是脂代谢紊乱、血压对前列腺的体积影响显著。Objective To evaluate the relationship between parameters of MS and prostate volume. Methods A total of 843 men aged 30 to 49 years were enrolled from August 2008 to July 2011. Prostate volume by ultrasonography, serum prostate specific antigen, digital rectal examination, urinary analysis, and MS-related parameters were investigated. We evaluated the correlations of prostate volume with MS and MS components. Results Prostate volume was larger in the MS group （28.3±5.5 ml） than in the non-MS group （23.2±5.6 ml, P〈0.05）. The prostate volumes in subjects with abnormal levels of fasting plasma glucose （FPG） （25.4±5.5 ml）, body mass index （BMI） （25.4±5.3 ml） and waist circumference （30.2±4.8 ml） were increased compared with those of subjects with normal parameters （23.6±5.5 ml, 22.6±5.5 and 23.5±5.3 ml, respectively, all P〈0.05）. The liner regression analysis showed that the FPG, BMI, WC, systolic pressure and triglyceride had a positive correlation with the prostate volume（r= 0. 216, 0. 397, 0. 411, 0. 170, 0.184, respectively; all P〈0.05）,but negatively related to HDL-C（r=-0.107,P〈0.05）. Conclusions The patients with abnormal FPG, BMI and waist circumference have larger prostate volume.

关 键 词：代谢综合征X 前列腺增生 

分 类 号：R589[医药卫生—内分泌]