实验性低血压大鼠腹主动脉的形态结构重建  

REMODELING OF MORPHORMETRIC STRUCTURE OF ABDOMINAL AORTA IN EXPERIMENTAL HYPOTENSIVE RATS

作　　者：李洪海[1] 姜宗来[1] 刘波[1] 张传森[1] 杨向群[1] 李玉泉[1] 丛兴忠[1] 

机构地区：[1]第二军医大学解剖学教研室生物医学工程研究所,上海200433

出　　处：《医用生物力学》2000年第1期1-7,共7页Journal of Medical Biomechanics

基　　金：国家自然科学基金!(19672072)

摘　　要：目的研究低血压状态下腹主动脉重建的规律，探讨腹主动脉的应力生长关系。方法在大鼠在肾动脉起点以下缩窄腹主动脉，建立实验性低血压大民模型，按不同的时相点，在血管组织切片上，观察腹主动脉的几何形态指标及其显微结构成份的变化。结果低血压导致腹主动脉几何形态、平滑肌、胶原纤维及弹性纤维呈“负增长”状态。结论腹主动脉壁面积减小出现早，趋势最稳定，且在各个时相点之间“负增长”率及总“负增长”幅度最大，是低血压大鼠动脉重建的特征性几何形态学指标。在血管三种显微结构成分中，平滑肌对应力的反应最敏感，总“负增长”幅度最大，是影响腹主动脉重建的主要因素。To study the rule of remodeling and the relationship between stress and growth of abdominal aorta in hypotension. Methods A hypotensive model was established in rats by constricting the abdominal aorta below the orifice of the left renal artery. The morphormetric parameters and microstructural components of the abdominal aorta was observed on the tissue slides of the artery in different phases. Results f Hypotension results in a negative increase of morphometric dimension of smooth muscle, collagenic fiber and elastic fiber. Conclusions: The decrease of the wall area occurred earlier than any other parameter, and its tendency of the changes is most stable, it's negative increase rate and total negative increase degree was the greatest at different phases, so the wall area is the characteristic guideline. Among the three microstructural components, Smooth muscle was the most sensitive to stress, it's total negative increase degree was the greatest, it was the important factor of arterial remodeling.

关 键 词：低血压 腹主动脉重建 平滑肌 大鼠 

分 类 号：R544.2[医药卫生—心血管疾病]