Germinal center kinases in immune regulation  

作　　者：Hailei Yin Zhubing Shi ShiJiao Cuicui Chen Wenjia Wang Mark I Greene Zhaocai Zhou 

机构地区：[1]Department of Trauma and Orthopaedics,General Hospital of Jinan Military Region,Jinan,China [2]No.401 Hospital of People Liberation Army,Qingdao,China [3]State Key Laboratory of Cell Biology,Institute of Biochemistry and Cell Biology,Shangha nst tutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,China [4]Department of Pathology and Laboratory Medicine,University of Pennsylvania,Philadelphia,PA,USA

出　　处：《Cellular & Molecular Immunology》2012年第6期439-445,共7页中国免疫学杂志（英文版）

基　　金：This work was supported by the 973 Program of the Ministry of Science and Technology of China （2010CB529700 and 2012CB910204）, the National Natural Science Foundation of China （NSFC10979005 and NSFC30970566） and the Science and Technology Commission of Shanghai Municipality （11JC14140000）. Dr ZZ is a scholar of the Hundred Talents Program of the Chinese Academy of Sciences. Dr Greene is supported by grants from the NIH, NCI, the Abramson Family Research Institute and the BCRF.

摘　　要：Germinal center kinases （GCKs） participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.Germinal center kinases （GCKs） participate in a variety of signaling pathways needed to regulate cellular functions including apoptosis, cell proliferation, polarity and migration. Recent studies have shown that GCKs are participants in both adaptive and innate immune regulation. However, the differential activation and regulatory mechanisms of GCKs, as well as upstream and downstream signaling molecules, remain to be fully defined. It remains unresolved whether and how GCKs may cross-talk with existing signaling pathways. This review stresses the progresses in research of GCKs relevant to the immune system.

关 键 词：germinal center kinases immune regulation signal transduction 

分 类 号：Q55[生物学—生物化学] TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]