黄芩苷缓释胶囊的研制  

Preparation of Baicalin Sustained-Release Capsules

作　　者：岳红坤[1] 王景翔[1] 周冉[1] 关倩[1] 

机构地区：[1]石家庄学院化工学院,河北石家庄050035

出　　处：《石家庄学院学报》2012年第6期26-29,共4页Journal of Shijiazhuang University

摘　　要：制备黄芩苷缓释胶囊,并通过体外释放度对其处方进行优化.以黄芩苷为原料药,羟丙甲纤维素(HPMC)、微晶纤维素(MCC)、乳糖、聚维酮(PVP)的乙醇溶液为辅料制备缓释胶囊,考察不同因素对释放度的影响,通过正交试验优化制备处方.优化后的黄芩苷缓释胶囊的处方为黄芩苷0.5 g,HPMC 0.25 g,MCC 0.2 g,PVP的乙醇溶液浓度为6%,乳糖0.25 g.研究方法简便、快速,体外释放度显示黄芩苷缓释胶囊处方设计比较合理,可进一步研发.The prescription is optimized through evaluating the release in vitro to prepare sustained-release baicalin capsules. With baicalin for apis, hydroxyl armour cellulose （HPMC）, microcrystalline cellulose （MCC）, lactose, PVP ethanol solution concentration to prepare the sustained-release capsules,influence on each different factor is investigated. Using the rthogonal test method,the optimization of prescription is completed. The optimized baicalin sustained-release capsule prescription is presented ： HPMC 0.25 g,baicalin 0.5 g, MCC 0.2 g, PVP ethanol solution concentration 6% ,lactose 0.25 g. This research method is simple and rapid ;the in-vitro release of baicalin also shows good rationality of the prescription design, and it can be further developed.

关 键 词：黄芩苷 缓释胶囊 体外释放度 

分 类 号：R944.5[医药卫生—药剂学]