生殖支原体感染的治疗及其对大环内酯类药物耐药性的研究现状  

Treatment of Mycoplasma genitalium infection and macrolide resistance in Mycoplasma genitalium

作　　者：刘排[1] 蒋娟[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2012年第6期387-390,共4页International Journal of Dermatology and Venereology

摘　　要：生殖支原体是引起非淋菌性尿道炎和宫颈炎的常见病原体之一，大环内酯类抗生素是目前治疗生殖支原体感染的一线药物。对大环内酯类抗生素耐药的生殖支原体临床菌株已经在阿奇霉素治疗失败的生殖支原体相关非淋菌性尿道炎患者中分离出来。生殖支原体对大环内酯类抗生素耐药突变位点主要位于23SrRNA基因和核糖体蛋白基因L4和L22基因。Mycoplasma genitalium （Mg） is a common cause of nongonococcal urethritis and cervicitis. Macrohde antibiotics, especially azithromycin, have been used as the flint-line therapy for patients with Mg infection. Macrolide-resistant Mg strains have been isolated from some patients with Mg-associated and treatment-resistant non-gonococcal urethfitis. It has been revealed that macrolide resistance is mainly associated with mutations in the domain V of 23S rRNA and in ribosomal protein genes IA and L22.

关 键 词：生殖支原体 抗药性 大环内酯类 

分 类 号：R759[医药卫生—皮肤病学与性病学]